Evidence map›Paper›PMID 29993277›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Removal of urea by electro-oxidation in a miniature dialysis device: a study in awake goats.

Maarten Wester, Maaike K van Gelder, Jaap A Joles, Frank Simonis, Diënty H M Hazenbrink, Theo W M van Berkel, Koen R D Vaessen, Walther H Boer, Marianne C Verhaar, Karin G F Gerritsen

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. From Home to Wearable Hemodialysis: Barriers, Progress, and Opportunities.Clinical journal of the American Society of Nephrology : CJASN · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maarten WesterDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Maaike K van GelderDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Jaap A JolesDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Frank SimonisNanodialysis B.V., Oirschot, The Netherlands.
Diënty H M HazenbrinkDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Theo W M van BerkelDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Koen R D VaessenCentral Laboratory Animal Research Facility, Utrecht University , Utrecht , The Netherlands.
Walther H BoerDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Marianne C VerhaarDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
Karin G F GerritsenDepartment of Nephrology and Hypertension, University Medical Center Utrecht and Regenerative Medicine Utrecht, Utrecht University , Utrecht , The Netherlands.
University Medical Center Utrecht · NLUtrecht University · NLCardialysis (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The key to success in developing a wearable dialysis device is a technique to safely and efficiently regenerate and reuse a small volume of dialysate in a closed-loop system. In a hemodialysis model in goats, we explored whether urea removal by electro-oxidation (EO) could be effectively and safely applied in vivo. A miniature dialysis device was built, containing 1 or 2 "EO units," each with 10 graphite electrodes, with a cumulative electrode surface of 585 cm

Indexed as

Wearable Electronic DevicesAcid-Base EquilibriumAcid-Base ImbalanceAnimalsCreatinineDialysis SolutionsDisease Models, AnimalEquipment DesignGoatsHemolysisMiniaturizationModels, BiologicalOxidation-ReductionPhosphatesPotassiumRenal DialysisCreatinineDialysis SolutionsPhosphatesPotassiumUreaelectro-oxidationhemodialysisin vivomedical deviceureawearable

Identifiers

PMID29993277
PMCPMC6293304
OpenAlexW2882430057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.