ArticleScientific reports2018
Engineering biofunctional in vitro vessel models using a multilayer bioprinting technique.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
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The trial behind it
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Who cites it
84 citing papers in PubMed.
- Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women's cerebrovascular health.Science advances · 2026Review
- High-Performance Regenerated Silk Fibers as Building Blocks of Tissue Scaffolds: The European THOR Project.Biomimetics (Basel, Switzerland) · 2026Article
- Engineering etiology-aligned in vitro models of human vessels.Microsystems & nanoengineering · 2026Review
- Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bio-Printed PCL Tracheal Graft in a Large Animal Model: Reproducible Short-Segment Regeneration and Preliminary Upgraded Long-Segment Reconstruction.Bioengineering (Basel, Switzerland) · 2026Article
- A Sacrificial 3D Printed Vessel-on-Chip Demonstrates a Versatile Approach to Model Granulation Tissue.Advanced healthcare materials · 2026Article
- Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Synergistic Combination of Additive One- and Two-Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis-on-a-Chip Systems.Engineering in life sciences · 2026Article
- Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025Review
- Progress in recapitulating morphogenesis of blood microvascular structures for microphysiological systems development.Biochemical Society transactions · 2025Article
- Development and deployment of a functional 3D-bioprinted blood vessel.Scientific reports · 2025Article
- Advances in Fibrin-Based Bioprinting for Skin Tissue Regeneration: Exploring Design, and Innovative Approaches.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Droplet-based bioprinting.Nature reviews. Methods primers · 2025Article
- Leveraging printability and biocompatibility in materials for printing implantable vessel scaffolds.Materials today. Bio · 2024Review
- Stem-Cell-Based Small-Diameter Blood Vessels with 3D Printing.Small science · 2024Article
- 3D-Printable Gelatin Methacrylate-Xanthan Gum Hydrogel Bioink Enabling Human Induced Pluripotent Stem Cell Differentiation into Cardiomyocytes.Journal of functional biomaterials · 2024Article
- The cutting-edge progress in bioprinting for biomedicine: principles, applications, and future perspectives.MedComm · 2024Review
- Review
- Improved Composite Hydrogel for Bioengineered Tracheal Graft Demonstrates Effective Early Angiogenesis.Journal of clinical medicine · 2024Article
- The Edifice of Vasculature-On-Chips: A Focused Review on the Key Elements and Assembly of Angiogenesis Models.ACS biomaterials science & engineering · 2024Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Recent advances in the field of bioprinting have led to the development of perfusable complex structures. However, most of the existing printed vascular channels lack the composition or key structural and physiological features of natural blood vessels or they make use of more easily printable but less biocompatible hydrogels. Here, we use a drop-on-demand bioprinting technique to generate in vitro blood vessel models, consisting of a continuous endothelium imitating the tunica intima, an elastic smooth muscle cell layer mimicking the tunica media, and a surrounding fibrous and collagenous matrix of fibroblasts mimicking the tunica adventitia. These vessel models with a wall thickness of up to 425 µm and a diameter of about 1 mm were dynamically cultivated in fluidic bioreactors for up to three weeks under physiological flow conditions. High cell viability (>83%) after printing and the expression of VE-Cadherin, smooth muscle actin, and collagen IV were observed throughout the cultivation period. It can be concluded that the proposed novel technique is suitable to achieve perfusable vessel models with a biofunctional multilayer wall composition. Such structures hold potential for the creation of more physiologically relevant in vitro disease models suitable especially as platforms for the pre-screening of drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.