Evidence map›Paper›PMID 29992897›Full record

ReviewMicrobiology spectrum2018

Small Regulatory RNAs in the Enterobacterial Response to Envelope Damage and Oxidative Stress.

Kathrin S Fröhlich, Susan Gottesman

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 76 citations in OpenAlex.

  1. A 3'UTR-derived small RNA modulates the life cycle of the cholera toxin-encoding filamentous phage, CTXϕ.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  9. Unexpected Richness of the Bacterial Small RNA World.Journal of molecular biology · 2025
    Review
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  18. Implication of the σMicrobiology spectrum · 2023
    Article
  19. Interactions and Insertion ofInternational journal of molecular sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kathrin S FröhlichDepartment of Biology I, Microbiology, LMU Munich, 82152 Martinsried, Germany.
Susan GottesmanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Max Planck Institute of Neurobiology · DENational Cancer Institute · US

Funding

Bacterial Functions Involved in Cell Growth ControlZIABC008714 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GOTTESMAN, SUSAN · 2009 to 2025
$20.3M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

The ability of bacteria to thrive in diverse habitats and to adapt to ever-changing environmental conditions relies on the rapid and stringent modulation of gene expression. It has become evident in the past decade that small regulatory RNAs (sRNAs) are central components of networks controlling the bacterial responses to stress. Functioning at the posttranscriptional level, sRNAs base-pair with cognate mRNAs to alter translation, stability, or both to either repress or activate the targeted transcripts; the RNA chaperone Hfq participates in stabilizing sRNAs and in promoting pairing between target and sRNA. In particular, sRNAs act at the heart of crucial stress responses, including those dedicated to overcoming membrane damage and oxidative stress, discussed here. The bacterial cell envelope is the outermost protective barrier against the environment and thus is constantly monitored and remodeled. Here, we review the integration of sRNAs into the complex networks of several major envelope stress responses of Gram-negative bacteria, including the RpoE (σ

Indexed as

Gene Expression Regulation, BacterialBacteriaBacterial ProteinsEnterobacteriaceaeEscherichia coliEscherichia coli ProteinsOxidative StressRegulonRepressor ProteinsRNA, BacterialRNA, MessengerRNA, Small UntranslatedSigma FactorStress, PhysiologicalTrans-ActivatorsTranscription FactorsBacterial ProteinsEscherichia coli ProteinsoxyR protein, E coliRepressor ProteinsRNA, BacterialRNA, MessengerRNA, Small UntranslatedSigma Factorsigma factor KatF protein, BacteriaSoxR protein, BacteriaSoxS protein, E coliTrans-ActivatorsTranscription Factors

Identifiers

PMID29992897
PMCPMC10361636
OpenAlexW2831432606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.