ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2019
Histopathological correlation of diffusion basis spectrum imaging metrics of a biopsy-proven inflammatory demyelinating brain lesion: A brief report.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Diffusion Basis Restricted Fraction as a Putative Magnetic Resonance Imaging Marker of Neuroinflammation: Histological Evidence, Diagnostic Accuracy, and Translational Potential.Life (Basel, Switzerland) · 2025Review
- Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity.Obesity (Silver Spring, Md.) · 2025Article
- Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.Brain, behavior, & immunity - health · 2024Article
- Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.bioRxiv : the preprint server for biology · 2023Article
- Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.Brain : a journal of neurology · 2021Review
- The impact of edema and fiber crossing on diffusion MRI metrics assessed in an ex vivo nerve phantom: Multi-tensor model vs. diffusion orientation distribution function.NMR in biomedicine · 2021Article
- Diffusion Histology Imaging Combining Diffusion Basis Spectrum Imaging (DBSI) and Machine Learning Improves Detection and Classification of Glioblastoma Pathology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Volumetric imaging of myelin in vivo using 3D inversion recovery-prepared ultrashort echo time cones magnetic resonance imaging.NMR in biomedicine · 2020Article
- Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2020Review
- Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions.Annals of clinical and translational neurology · 2020Article
- Diffusion basis spectrum imaging for identifying pathologies in MS subtypes.Annals of clinical and translational neurology · 2019Article
- Incorporating non-linear alignment and multi-compartmental modeling for improved human optic nerve diffusion imaging.NeuroImage · 2019Article
- Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging.Frontiers in human neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Diffusion basis spectrum imaging (DBSI) models diffusion-weighted magnetic resonance imaging (MRI) signals as a combination of discrete anisotropic diffusion tensors and a spectrum of isotropic diffusion tensors. Here, we report the histopathological correlates of DBSI in the biopsied brain tissue of a patient with an inflammatory demyelinating lesion typical of multiple sclerosis (MS). Increased radial diffusivity (marker of demyelination), decreased fiber fraction (apparent axonal density), elevated nonrestricted isotropic fraction (marker of vasogenic edema), but unchanged axial diffusivity (marker of integrity of residual axons) seen in the lesion appeared consistent with histopathological findings of inflammatory demyelination with relative axonal sparing. Our report supports the application of DBSI as a biomarker in human studies of MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.