Evidence map›Paper›PMID 29992766›Full record

ArticleJournal of biophotonics2018

Segmentation of Drosophila heart in optical coherence microscopy images using convolutional neural networks.

Lian Duan, Xi Qin, Yuanhao He, Xialin Sang, Jinda Pan, Tao Xu, Jing Men, Rudolph E Tanzi, Airong Li, Yutao Ma and 1 more

Abstract read
In one paragraph

Article in Journal of biophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2025
    Article
  2. Attention LSTM U-Net model forBiomedical optics express · 2024
    Article
  3. Article
  4. Article
  5. Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020
    Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lian DuanDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, Pennsylvania.ORCID 0000-0002-6264-8465
Xi QinDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, Pennsylvania.
Yuanhao HeDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, Pennsylvania.
Xialin SangDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, Pennsylvania.
Jinda PanSchool of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, China.
Tao XuDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, Pennsylvania.
Jing MenDepartment of Bioengineering, Lehigh University, Bethlehem, Pennsylvania.
Rudolph E TanziGenetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Airong LiGenetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Yutao MaState Key Laboratory of Software Engineering, Wuhan University, Wuhan, China.
Chao ZhouDepartment of Electrical and Computer Engineering, Lehigh University, Bethlehem, Pennsylvania.ORCID 0000-0002-8679-3413
Lehigh University · USHarvard University · USTianjin University · CNWuhan University · CN

Funding

High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids.R01EB025209 · NIBIB · WASHINGTON UNIVERSITY · PI ZHOU, CHAO · 2017 to 2021
$1.4M
Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted ImaR00EB010071 · NIBIB · LEHIGH UNIVERSITY · PI ZHOU, CHAO · 2012 to 2013
$479k
Novel optical imaging and pacing platform for developmental cardiologyR15EB019704 · NIBIB · LEHIGH UNIVERSITY · PI BERDICHEVSKY, YEVGENY · 2015 to 2015
$470k
Space-division multiplexing optical coherence tomography for large-scale, millisecond resolution imaging of neural activityR21EY026380 · NEI · LEHIGH UNIVERSITY · PI BERDICHEVSKY, YEVGENY, ZHOU, CHAO · 2015 to 2016
$468k
Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted ImaK99EB010071 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHOU, CHAO · 2011 to 2011
$90k
NEI NIH HHS R21 EY026380NIBIB NIH HHS K99 EB010071NIBIB NIH HHS R00 EB010071NIBIB NIH HHS R01 EB025209NIBIB NIH HHS R15 EB019704
6 · The paper itself

Abstract

Convolutional neural networks (CNNs) are powerful tools for image segmentation and classification. Here, we use this method to identify and mark the heart region of Drosophila at different developmental stages in the cross-sectional images acquired by a custom optical coherence microscopy (OCM) system. With our well-trained CNN model, the heart regions through multiple heartbeat cycles can be marked with an intersection over union of ~86%. Various morphological and dynamical cardiac parameters can be quantified accurately with automatically segmented heart regions. This study demonstrates an efficient heart segmentation method to analyze OCM images of the beating heart in Drosophila.

Indexed as

Drosophila melanogasterNeural Networks, ComputerTomography, Optical CoherenceAnimalsHeartImage Processing, Computer-Assisteddeep learningDrosophila heartneural networksoptical coherence microscopy

Identifiers

PMID29992766
PMCPMC6289629
OpenAlexW2963876870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.