Evidence map›Paper›PMID 29992746›Full record

ArticleCancer medicine2018

Association between serum levels of insulin-like growth factor-1, bioavailable testosterone, and pathologic Gleason score.

Myong Kim, Jong Won Kim, Jong Keun Kim, Sang Mi Lee, Cheryn Song, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Myong KimDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-6995-6850
Jong Won KimDepartment of Urology, Korea Cancer Center Hospital, Seoul, Korea.
Jong Keun KimDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sang Mi LeeDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Cheryn SongDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
In Gab JeongDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0003-4093-832X
Jun Hyuk HongDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Choung-Soo KimDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hanjong AhnDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-7608-5352
Ulsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe evaluated the association between serum levels of insulin-like growth factor-1 (IGF-1), bioavailable testosterone, and surgical Gleason score (GS).

methodsWe analyzed 793 patients who underwent radical prostatectomy and 272 men with negative prostate biopsy. Serum levels of IGF-1 and testosterone were measured before surgery or biopsy.

resultsThe mean IGF-1 levels of prostate cancer patients and men with a negative biopsy were 143.8 and 118.9 ng/mL, respectively (P < 0.001). Men with high serum IGF-1 were more likely to have prostate cancer (highest vs lowest quartile, odds ratio [OR] = 3.35; P

conclusionsSerum levels of IGF-1 and bioavailable testosterone show inverse associations with high surgical GS. This suggests that high-grade prostate cancer develops independently of these two substances.

Indexed as

Insulin-Like Growth Factor IAgedBiomarkersBiopsyComorbidityHumansInsulin-Like Growth Factor Binding Protein 3MaleMiddle AgedNeoplasm GradingNeoplasm MetastasisNeoplasm StagingProstatectomyProstatic NeoplasmsTestosteroneTumor BurdenBiomarkersIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ITestosteronebioavailable testosteroneGleason scoreinsulin-like growth factor-1pathologyprostate cancer

Identifiers

PMID29992746
PMCPMC6089192
OpenAlexW2862561279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.