Evidence map›Paper›PMID 29992704›Full record

ArticleAging cell2018

Plasma proteomic signature of age in healthy humans.

Toshiko Tanaka, Angelique Biancotto, Ruin Moaddel, Ann Zenobia Moore, Marta Gonzalez-Freire, Miguel A Aon, Julián Candia, Pingbo Zhang, Foo Cheung, Giovanna Fantoni and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 377 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
377citing papers in PubMed, 3 pooled it
34.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

377 citing papers in PubMed, 3 syntheses or guidelines pooled it, 561 citations in OpenAlex.

  1. Pooled it
  2. Proteomic Markers of Aging and Longevity: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. ReducedbioRxiv : the preprint server for biology · 2026
    Article
  20. Article

317 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Toshiko TanakaLongitudinal Study Section, Translational Gerontology Branch, NIA, NIH, Baltimore, Maryland.
Angelique BiancottoTrans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland.
Ruin MoaddelLaboratory of Clinical Investigation, NIA, NIH, Baltimore, Maryland.
Ann Zenobia MooreLongitudinal Study Section, Translational Gerontology Branch, NIA, NIH, Baltimore, Maryland.
Marta Gonzalez-FreireLongitudinal Study Section, Translational Gerontology Branch, NIA, NIH, Baltimore, Maryland.
Miguel A AonLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Julián CandiaTrans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland.
Pingbo ZhangWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Foo CheungTrans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland.
Giovanna FantoniTrans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland.
CHI consortiumTrans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland.
Richard D SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Luigi FerrucciLongitudinal Study Section, Translational Gerontology Branch, NIA, NIH, Baltimore, Maryland.
National Institutes of Health · USJohns Hopkins Medicine · USJohns Hopkins University · USNational Institute on Drug Abuse · US

Funding

Center for Human Immunology ZICAI001226 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2018 to 2025
$34.1M
GESTALT-Genetic and Epigenetic Signatures of Translational Aging Laboratory TestingZIAAG000996 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2015 to 2025
$7.6M
Oxidative stress and the pathogenesis of sarcopenia and disability in older womenR01AG027012 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2005 to 2018
$3.6M
Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older WomenR56AG027012 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2008 to 2008
$391k
NIA NIH HHS R01 AG027012NIA NIH HHS R56 AG027012
6 · The paper itself

Abstract

To characterize the proteomic signature of chronological age, 1,301 proteins were measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in a population of 240 healthy men and women, 22-93 years old, who were disease- and treatment-free and had no physical and cognitive impairment. Using a p ≤ 3.83 × 10

Indexed as

HealthProteomicsAdultAgedAged, 80 and overAgingFemaleHumansMaleMiddle AgedMolecular Sequence AnnotationReproducibility of ResultsYoung Adultagingaptamershealthy aginghumansplasmaproteomics

Identifiers

PMID29992704
PMCPMC6156492
OpenAlexW2815133411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.