Evidence map›Paper›PMID 29992456›Full record

ArticleSleep & breathing = Schlaf & Atmung2019

Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea.

Xiandong Gu, Wei Yang, Xuming Luo, Xiongbiao Wang, Jihong Tang, Zhuying Cai

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in genetics · 2023
    Article
  4. Article
  5. [Research status of Epstein Barr virus in children with adenotonsillar hypertrophy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiandong GuDepartment of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, LanXi Road, Shanghai, 200063, China.
Wei YangDepartment of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, LanXi Road, Shanghai, 200063, China.
Xuming LuoDepartment of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, LanXi Road, Shanghai, 200063, China.
Xiongbiao WangDepartment of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, LanXi Road, Shanghai, 200063, China.
Jihong TangDepartment of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, LanXi Road, Shanghai, 200063, China.
Zhuying CaiDepartment of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, LanXi Road, Shanghai, 200063, China. czy224cai@yeah.net.
Shanghai University of Traditional Chinese Medicine · CN

Funding

Shanghai Municipal Commission of Health and Family Planning science and technology innovation project on Traditional Chinese medicine ZYKC201703008
6 · The paper itself

Abstract

purposeObstructive sleep apnea (OSA) is induced by obstruction of the upper airway, which can raise multiple health risks. This study is designed to reveal the key genes involved in OSA.

methodsGSE38792 was extracted from Gene Expression Omnibus database, including ten visceral adipose tissues from OSA patients and eight visceral adipose tissues from normal controls. Differential expression analysis was conducted using limma package, and then the functions of the differentially expressed genes (DEGs) were analyzed using DAVID database, followed by protein-protein interaction (PPI) network, and integrated regulatory network analysis was performed using Cytoscape software.

resultsA total of 368 DEGs (176 upregulated and 192 downregulated) were identified in OSA samples. Epstein-Barr virus infection (involving IL10RB, MAPK9, and MAPK10) and olfactory transduction were the main pathways separately enriched for the upregulated genes and the downregulated genes. After the PPI network was built, the top ten network nodes (such as TXN) were selected according to node degrees. Two significant PPI network modules were identified. Moreover, the integrated regulatory network was constructed.

conclusionIL10RB, MAPK9, MAPK10, and TXN might function in the pathogenesis of OSA.

Indexed as

Computational BiologyAdipose TissueDown-RegulationEpstein-Barr Virus InfectionsGene Expression ProfilingGene Regulatory NetworksHumansInterleukin-10 Receptor beta SubunitMitogen-Activated Protein Kinase 10Mitogen-Activated Protein Kinase 9Oligonucleotide Array Sequence AnalysisProtein Interaction Domains and MotifsReference ValuesSleep Apnea, ObstructiveThioredoxinsUp-RegulationIL10RB protein, humanInterleukin-10 Receptor beta SubunitMitogen-Activated Protein Kinase 10Mitogen-Activated Protein Kinase 9ThioredoxinsTXN protein, humanDifferentially expressed genesEnrichment analysisIntegrated regulatory networkObstructive sleep apneaProtein-protein interaction network

Identifiers

PMID29992456
OpenAlexW2876922033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.