ArticleInternational journal of bipolar disorders2018
Regional cortical thinning in young adults with schizophrenia but not psychotic or non-psychotic bipolar I disorder.
Article in International journal of bipolar disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Meta-analysis of cortical thickness reduction in adult schizophrenia.Journal of psychiatry & neuroscience : JPNPooled it
- Vertexwise Cortical Deviation Mapping (VCDM): A precision approach to cortical thickness assessment in non-affective psychosis.Brain imaging and behavior · 2026Article
- Frontotemporal cortical thinning and insular surface area reduction in schizophrenia with predominant negative symptoms.BMC psychiatry · 2026Article
- Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations.Molecular psychiatry · 2026Article
- Diffusion basis spectrum imaging of white matter in schizophrenia and bipolar disorder.Brain imaging and behavior · 2025Article
- Subtyping Schizophrenia Patients Based on Patterns of Structural Brain Alterations.Schizophrenia bulletin · 2022Article
- Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles.Frontiers in cell and developmental biology · 2022Article
- Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank.Translational psychiatry · 2021Article
- Strategies to solve the reverse inference fallacy in future MRI studies of schizophrenia: a review.Brain imaging and behavior · 2021Review
- Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity.NPJ schizophrenia · 2021Article
- Neuroanatomic and Functional Neuroimaging Findings.Current topics in behavioral neurosciences · 2021Article
- Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.Schizophrenia research · 2020Article
- Depth-dependent abnormal cortical myelination in first-episode treatment-naïve schizophrenia.Human brain mapping · 2020Article
- Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study.NeuroImage. Clinical · 2020Article
- Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia.Neuroscience bulletin · 2019Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSchizophrenia shares some genetic risk and clinical symptoms with bipolar disorder. Clinical heterogeneity across subjects is thought to contribute to variable structural imaging findings across studies. The current study investigates cortical thickness in young adults diagnosed with schizophrenia or bipolar I disorder with a history of hyperthymic mania. We hypothesize that cortical thickness will be most similar between SCZ and the psychotic bipolar 1 disorder subtype.
methodsPatients with schizophrenia (n = 52), psychotic bipolar I disorder (PBD; n = 49) and non-psychotic bipolar I disorder (NPBD; n = 24) and healthy controls (n = 40) were scanned in a 3T Trio MRI. The thickness of 34 cortical regions was estimated with FreeSurfer, and analyzed using univariate analyses of variance. Relationships to psychotic (SAPS) and negative (SANS) symptoms were investigated using linear regression.
resultsCortical thickness showed significant group effects, after covarying for sex, age, and intracranial volume (p = 0.001). SCZ subjects had thinner paracentral, inferior parietal, supramarginal and fusiform cortices compared to CON. Caudal anterior cingulate cortical thickness was increased in SCZ, PBD and NPBD. Cortical thickness in PBD and NPBD were not significantly different from controls. Significant partial correlations were observed for SAPS severity with middle temporal (r = - 0.26; p = 0.001) and fusiform (- 0.26; p = 0.001) cortical thickness.
conclusionsIndividuals with SCZ displayed significantly reduced cortical thickness in several cortical regions compared to both CON and bipolar. We found that SCZ participants had significant cortical thinning relative to CON and bipolar disorder most significantly in the frontal (i.e. paracentral), parietal (i.e. inferior parietal, supramarginal), and temporal (i.e. middle temporal, fusiform) cortices.
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