ArticleClinical rheumatology2018
Adverse childhood experience and rheumatic diseases.
Article in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Systematic review and meta-analysis of post-traumatic stress disorder as a risk factor for multiple autoimmune diseases.Frontiers in psychiatry · 2025Pooled it
- Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies.Brain and behavior · 2023Pooled it
- Prevalence and transient impact of childhood abuse and neglect on health-related quality of life in Mexican patients with early rheumatoid arthritis.Clinical rheumatology · 2026Article
- Childhood trauma and systemic lupus erythematosus activity in Tunisian patients: exploring the mediating role of post-traumatic stress disorder.Lupus science & medicine · 2026Article
- Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE.Lupus science & medicine · 2026Article
- From childhood shadows to adult aches: a prospective cohort study on adverse childhood experiences, depressive symptoms, and incident arthritis in middle-aged and older Chinese adults.European journal of medical research · 2025Article
- Adverse childhood experiences and arthritis risk: exploring behavioral and psychological mediators in the behavioral risk factor surveillance system.Frontiers in public health · 2025Article
- The Mediating Effects of Chronic Diseases in the Relationship Between Adverse Childhood Experiences and Trajectories of Depressive Symptoms in Later Life: A Nationwide Longitudinal Study.Healthcare (Basel, Switzerland) · 2024Article
- Can adverse childhood experiences predict chronic health conditions? Development of trauma-informed, explainable machine learning models.Frontiers in public health · 2023Article
- Heterogeneous adverse childhood experiences and cognitive function in an elderly Chinese population: a cohort study.BMJ open · 2022Article
- Exploring the intersection of adverse childhood experiences, pediatric chronic pain, and rheumatic disease.Pediatric rheumatology online journal · 2022Article
- Association of childhood physical and sexual abuse with arthritis in adulthood: Findings from a population-based study.Preventive medicine reports · 2021Article
- Association of Child Abuse and Systemic Lupus Erythematosus in Black Women During Adulthood.Arthritis care & research · 2021Article
- Article
- Adverse childhood experiences predict reaction to multiple sclerosis diagnosis.Health psychology openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that the adaptive stress response may be disrupted by life adverse events such as childhood maltreatment. To investigate if the number of adverse childhood experiences (ACEs) increases susceptibility to systemic lupus erythematosus (SLE), spondyloarthritis (SpA), scleroderma (SSc), and rheumatoid arthritis (RA), we interviewed 315 patients with rheumatic disease (100 SLE; 40 SSc; 60 SpA; 115 RA) and 272 controls, using questions of the ACEs study questionnaire validated to ask about experiences of childhood abuse, negligence, domestic violence, and household dysfunctions. The questionnaire score ranges from zero (best result) to 8 (worst scenario). Patients and controls did not differ regarding the median number of ACEs (3 in both groups, patient IQR = 2.5-5 vs. control IQR = 2-5, p = 0.45). Among the patients, 63.8% (201/315) presented ACE score ≥ 3, compared with 59.9% (163/272) of the controls (p = 0.31). The proportion of patients with at least 3 ACEs did also not differ among those with different rheumatic diseases. Specifically, 64% (64/100) of those with SLE, 60% (24/40) of those with SSc, 60% (36/60) of those with SpA, and 66.9% (77/115) of those with RA reported at least 3 ACEs. There was also no difference between the distribution of ACE scores and number of individuals with ACEs ≥ 3 between patients with different rheumatic diseases and controls. Nevertheless, there was a trend for association between higher ACE score and susceptibility to RA (p = 0.06). In this setting, the occurrence of ACEs was not associated with susceptibility to rheumatic diseases in adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.