Evidence map›Paper›PMID 29992384›Full record

Observational studyEuropean radiology2019

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge.

Saba Shirvani, Paweł Tokarczuk, Ben Statton, Marina Quinlan, Alaine Berry, James Tomlinson, Peter Weale, Bernd Kühn, Declan P O'Regan

Open access · hybridAbstract readObservational StudyVideo-Audio Media
In one paragraph

Observational study in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Saba ShirvaniMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Paweł TokarczukMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Ben StattonMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Marina QuinlanMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Alaine BerryMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
James TomlinsonMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Peter WealeSiemens Healthcare Ltd, Frimley, UK.
Bernd KühnSiemens Healthcare GmbH, Erlangen, Germany.
Declan P O'ReganMedical Research Council (MRC), London Institute of Medical Sciences (LMS), Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. declan.oregan@imperial.ac.uk.ORCID http://orcid.org/0000-0002-0691-0270
Hammersmith Hospital · GBSiemens Healthineers (Germany) · DESiemens (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T

methodsIn a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T

resultsInter-study correlation of whole-kidney RBF was good for both single-TI (r

conclusionsFree-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge. KEY POINTS: • Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T. • This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T

Indexed as

AdultFemaleHealthy VolunteersHumansKidneyMagnetic Resonance ImagingMaleProspective StudiesRenal ArteryReproducibility of ResultsSpin LabelsVasodilationVasodilator AgentsSpin LabelsVasodilator AgentsBlood flow velocityComputer-assisted image processingMagnetic resonance imagingRenal circulationVasodilator agents

Identifiers

PMID29992384
PMCPMC6291439
OpenAlexW2874043697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.