Evidence map›Paper›PMID 29992382›Full record

ArticleBasic research in cardiology2018

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y

Jonathon P Audia, Xi-Ming Yang, Edward S Crockett, Nicole Housley, Ehtesham Ul Haq, Kristen O'Donnell, Michael V Cohen, James M Downey, Diego F Alvarez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 175 citations in OpenAlex.

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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jonathon P AudiaDepartment of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA. jaudia@southalabama.edu.
Xi-Ming YangDepartment of Physiology and Cell Biology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA.
Edward S CrockettCenter for Lung Biology, University of South Alabama College of Medicine, Medical Sciences Building, Mobile, AL, 36688, USA.
Nicole HousleyDepartment of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA.
Ehtesham Ul HaqDepartment of Medicine, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA.
Kristen O'DonnellDepartment of Pharmacology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA.
Michael V CohenDepartment of Physiology and Cell Biology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA.
James M DowneyDepartment of Physiology and Cell Biology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA.
Diego F AlvarezCenter for Lung Biology, University of South Alabama College of Medicine, Medical Sciences Building, Mobile, AL, 36688, USA. dalvarez@southalabama.edu.
University of South Alabama · US

Funding

Caspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0M
Foundation for the National Institutes of Health Grant #R01HL118334NHLBI NIH HHS R01 HL118334
6 · The paper itself

Abstract

Patients with acute myocardial infarction receive a P2Y

Indexed as

Adenosine MonophosphateAnimalsCaspase 1DipeptidesDisease Models, AnimalDrug Therapy, CombinationEnergy MetabolismInterleukin-1betaIsolated Heart PreparationMaleMitochondria, HeartMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumpara-AminobenzoatesPurinergic P2 Receptor AntagonistsAdenosine MonophosphatebelnacasancangrelorCaspase 1DipeptidesIL1B protein, ratInterleukin-1betaP2ry12 protein, ratpara-AminobenzoatesPurinergic P2 Receptor AntagonistsReceptors, Purinergic P2Receptors, Purinergic P2Y12TicagrelorCardioprotectionCaspase-1Ischemia/reperfusion injuryMyocardial infarctionP2Y12 receptor antagonistVX-765

Identifiers

PMID29992382
PMCPMC6396295
OpenAlexW2840143818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.