ReviewCurrent hypertension reports2018
The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia?
Review in Current hypertension reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association between blood lipid levels and preeclampsia: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Maternal hyperuricemia and adverse maternal-fetal outcomes: a systematic review and meta-analysis of observational studies.Frontiers in medicine · 2026Pooled it
- The prognostic role of serum uric acid levels in preeclampsia: A meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Elevated serum uric acid before 20 weeks of gestation increases the risk of preeclampsia.Scientific reports · 2026Article
- Role of serum high-sensitive C-reactive protein to predict severity of pre-eclampsia in a high-population resource-poor country: a prospective observational study.Journal of rural medicine : JRM · 2025Article
- Evaluating oxidative stress targeting treatments inFrontiers in cell and developmental biology · 2025Article
- Effect of serum uric acid level on reproductive outcome in women without polycystic ovary syndrome undergoing in vitro fertilization.Reproductive biology and endocrinology : RB&E · 2024Article
- The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Risk factors for preeclampsia in patients with chronic kidney disease primarily focused on stage 1 CKD. Are referred and registered patients alike?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases.Biomolecules · 2023Review
- The relation between serum uric acid and severity of preeclampsia in pregnant women: a cross-sectional study.Przeglad menopauzalny = Menopause review · 2023Article
- Impact of Angiogenic and Cardiovascular Biomarkers for Prediction of Placental Dysfunction in the First Trimester of Pregnancy.Biomedicines · 2023Article
- Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study.International journal of epidemiology · 2023Article
- Factors Involved in Endothelial Dysfunction Related to Angiogenic Disbalance and Oxidative Stress, in Women at High Risk of Term Pre-Eclampsia.Antioxidants (Basel, Switzerland) · 2022Article
- Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes.Archives of gynecology and obstetrics · 2022Article
- Development and Validation of Multi-Stage Prediction Models for Pre-eclampsia: A Retrospective Cohort Study on Chinese Women.Frontiers in public health · 2022Article
- Characterizing and Evaluating Diurnal Salivary Uric Acid Across Pregnancy Among Healthy Women.Frontiers in endocrinology · 2022Article
- Uric acid participating in female reproductive disorders: a review.Reproductive biology and endocrinology : RB&E · 2021Review
- Assessing the Role of Uric Acid as a Predictor of Preeclampsia.Frontiers in physiology · 2021Article
- Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective.Frontiers in pharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewBecause of the significant discrepancies on this topic, this review will focus on the role of uric acid in PE, uric acid as a predictor of preeclampsia and fetal growth retardation. We considered eligible review and original articles relevant to the research question. RECENT
findingsHypertensive disorders of pregnancy such as preeclampsia (PE) are a major cause of both maternal and fetal morbidity and mortality worldwide. Uric acid has been reported as a key factor contributing to the pathogenesis of PE. Some studies have indicated that serum uric acid levels increase with the severity of PE, while several studies have shown contradictory results. Some studies suggested high uric acid levels lead to PE, while others state that PE causes an increase in uric acid levels. Despite the strong association of uric acid in the pathogenesis of preeclampsia, current data is still contradictory hence genetic and high-end laboratory investigations may clarify this enigma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.