ArticleCerebral cortex (New York, N.Y. : 1991)2019
Microglia: An Intrinsic Component of the Proliferative Zones in the Fetal Rhesus Monkey (Macaca mulatta) Cerebral Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Radial astroglia cooperate with microglia to clear neuronal cell bodies during zebrafish optic tectum development.Cell reports · 2025Article
- The Role of Prenatal Microglial Activation and Its Sex Differences in the Development of Neuropsychiatric Disorders and Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- Copy number variants and the tangential expansion of the cerebral cortex.Nature communications · 2025Article
- Physiological roles of embryonic microglia and their perturbation by maternal inflammation.Frontiers in cellular neuroscience · 2025Review
- The role of microglia in early neurodevelopment and the effects of maternal immune activation.Seminars in immunopathology · 2024Review
- Article
- At the crux of maternal immune activation: Viruses, microglia, microbes, and IL-17A.Immunological reviews · 2022Review
- Primate Models as a Translational Tool for Understanding Prenatal Origins of Neurodevelopmental Disorders Associated With Maternal Infection.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Translational Utility of the Nonhuman Primate Model.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Nonhuman Primates in Translational Research.Annual review of animal biosciences · 2022Review
- Embryonic Pericytes Promote Microglial Homeostasis and Their Effects on Neural Progenitors in the Developing Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Human Pluripotent Stem Cell Differentiation to Microglia.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Fetal Rhesus Monkey First Trimester Zika Virus Infection Impacts Cortical Development in the Second and Third Trimesters.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Development of the Neuro-Immune-Vascular Plexus in the Ventricular Zone of the Prenatal Rat Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Greater Number of Microglia in Telencephalic Proliferative Zones of Human and Nonhuman Primate Compared with Other Vertebrate Species.Cerebral cortex communications · 2021Article
- Transient microglial absence assists postmigratory cortical neurons in proper differentiation.Nature communications · 2020Article
- The fundamental building blocks of cortical development are established in human exencephaly.Pediatric research · 2020Article
- Microglia enhances proliferation of neural progenitor cells in anEXCLI journal · 2020Article
- Periventricular microglial cells interact with dividing precursor cells in the nonhuman primate and rodent prenatal cerebral cortex.The Journal of comparative neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Microglial cells are increasingly recognized as modulators of brain development. We previously showed that microglia colonize the cortical proliferative zones in the prenatal brain and regulate the number of precursor cells through phagocytosis. To better define cellular interactions between microglia and proliferative cells, we performed lentiviral vector-mediated intraventricular gene transfer to induce enhanced green fluorescent protein expression in fetal cerebrocortical cells. Tissues were collected and counterstained with cell-specific markers to label microglial cells and identify other cortical cell types. We found that microglial cells intimately interact with the radial glial scaffold and make extensive contacts with neural precursor cells throughout the proliferative zones, particularly in the rhesus monkey fetus when compared to rodents. We also identify a subtype of microglia, which we term 'periventricular microglia', that interact closely with mitotic precursor cells in the ventricular zone. Our data suggest that microglia are structural modulators that facilitate remodeling of the proliferative zones as precursor cells migrate away from the ventricle and may facilitate the delamination of precursor cells. Taken together, these results indicate that microglial cells are an integral component of cortical proliferative zones and contribute to the interactive milieu in which cortical precursor cells function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.