ArticleBioactive materials2018
Study of locust bean gum reinforced cyst-chitosan and oxidized dextran based semi-IPN cryogel dressing for hemostatic application.
Article in Bioactive materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 86 citations in OpenAlex.
- Degree of Carboxymethyl Substitution on Tara Gum Influences the Mucoadhesive and Physicochemical Performance of Gastroretentive Tablets.AAPS PharmSciTech · 2026Article
- Hydrogel Loaded with Aminoethyl Anisamide-Modified Exosomes Attenuates Hepatic Fibrosis by Targeting Activated Hepatic Stellate Cells.ACS nano · 2025Article
- Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding.Journal of nanobiotechnology · 2025Article
- Injectable carboxymethyl chitosan/oxidized dextran hydrogels containing zoledronic acid modified strontium hydroxyapatite nanoparticles.RSC advances · 2025Article
- Cysteine Conjugation: An Approach to Obtain Polymers with Enhanced Muco- and Tissue Adhesion.International journal of molecular sciences · 2024Review
- Cryogels: Advancing Biomaterials for Transformative Biomedical Applications.Pharmaceutics · 2023Review
- Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration.Bioactive materials · 2022Article
- Advances of Hydrogel Therapy in Periodontal Regeneration-A Materials Perspective Review.Gels (Basel, Switzerland) · 2022Review
- Multi-Crosslinked Strong and Elastic Bioglass/Chitosan-Cysteine Hydrogels with Controlled Quercetin Delivery for Bone Tissue Engineering.Pharmaceutics · 2022Article
- L-Cysteine Modified Chitosan Nanoparticles and Carbon-Based Nanostructures for the Intranasal Delivery of Galantamine.Polymers · 2022Article
- Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction.Bioactive materials · 2022Article
- Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration.Bioactive materials · 2022Article
- Cellulose Cryogels as Promising Materials for Biomedical Applications.International journal of molecular sciences · 2022Review
- Thermosensitive Bioadhesive Hydrogels Based on Poly(Pharmaceutics · 2021Article
- Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment.Bioactive materials · 2021Article
- Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications.Biomacromolecules · 2021Review
- Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing.Beilstein journal of organic chemistry · 2021Review
- Self-Healing Hydrogels and Cryogels from Biodegradable Polyurethane Nanoparticle Crosslinked Chitosan.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Fabrication of novel bone haemostasis sheet by using sugar-containing hydroxyapatite and plant-derived polymer.Royal Society open science · 2019Article
- Exploring cutting-edge hydrogel technologies and their biomedical applications.Bioactive materials · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe blood loss due to traumatic injuries remains one of the leading causes of death in emergency settings. Chitosan continues to be the candidate material for hemostatic applications due to its inherent hemostatic properties. However, available chitosan-based dressings have been reported to have an acidic odor at the wound site due to the incorporation of acid based solvents for their fabrication and deformation under compression owing to low mechanical strength limiting its usability. In the present study semi-IPN cryogel was fabricated via Schiff's base cross-linking between the polyaldehyde groups of oxidized dextran and thiolated chitosan in presence of locust bean gum (LBG) known for its hydrophilicity. Polymerization at -12 °C yielded macroporous semi-IPN cryogels with an average pore size of 124.57 ± 20.31 μm and 85.46% porosity. The hydrophobicity index of LBG reinforced semi-IPN cryogel was reduced 2.42 times whereas the swelling ratio was increased by 156.08% compare to control cryogel. The increased hydrophilicity and swelling ratio inflated the compressive modulus from 28.1 kPa to 33.85 for LBG reinforced semi-IPN cryogel. The structural stability and constant degradation medium pH were also recorded over a period of 12 weeks. The cryogels demonstrated lower adsorption affinity towards BSA. The cytotoxicity assays (direct, indirect) with 3T3-L1 fibroblast cells confirmed the cytocompatibility of the cryogels. The hemolysis assay showed <5% hemolysis confirming blood compatibility of the fabricated cryogel, while whole blood clotting and platelet adhesion assays confirmed the hemostatic potential of semi-IPN cryogel.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.