ArticleOpen forum infectious diseases2018
Diagnostic Approach for Classic Compared With Localized Whipple Disease.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Prevalence, characteristics, and clinical outcomes of Whipple disease in patients initially diagnosed with a rheumatic disease: a large nested case-control study in the Eastern Netherlands.EULAR rheumatology open · 2026Article
- Whipple disease presenting with severe weight loss, seronegative inflammatory arthritis, and culture-negative endocarditis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- When it's not RA: unmasking Whipple's disease in seronegative, difficult-to-treat rheumatoid arthritis.Clinical rheumatology · 2026Review
- Deciphering whipple's disease complexity.Clinical and experimental medicine · 2026Review
- Article
- Whipple Disease Initial Presentation as Supraclavicular Lymphadenopathy in a Patient With Rheumatoid Arthritis: A Diagnostic Challenge.International journal of surgical pathology · 2025Article
- Article
- Whipple's disease of the respiratory system: A case report.Experimental and therapeutic medicine · 2024Article
- Lyme disease and Whipple's disease: a comprehensive review for the rheumatologist.Advances in rheumatology (London, England) · 2024Review
- The Brief Case: Tropheryma whipplei Infection Resulting in Neurological Symptoms.Journal of clinical microbiology · 2022Review
- Article
- Whipple's disease: imaging contribution for a challenging case.BMJ case reports · 2020Article
- Whipple's Disease Affecting Ileal Peyer's Patches: The First Case Report.Case reports in pathology · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhipple disease (WD), a rare systemic infection caused by
methodsWe retrospectively collected all cases of WD diagnosed from 1994 to 2016. Microbiology laboratory and anatomic pathology databases were queried. Case characteristics and disease clinical phenotypes (classical, localized WD arthritis, and localized central nervous system [CNS] disease) were described. The diagnostic approach and testing yield were analyzed and reported.
resultsThirty-three cases of WD were diagnosed (18 classic WD [CWD], 9 localized WD arthritis [LWD], 6 CNS WD). Misdiagnosis and delay in diagnosis were frequent. Diagnostic approach and test yield differed by classical vs localized WD involvement. Small bowel tissue biopsy PAS stain/PCR was overwhelmingly positive (86%/92%) in CWD, yet seldom positive (12%/42%) in LWD (
conclusionsThese results support the role of small bowel biopsy PAS stain/PCR in the diagnosis of CW, though this approach may be of limited utility in LWD or CNS WD without gastrointestinal symptoms. Affected joint synovial fluid or cerebrospinal fluid PCR was frequently positive in both CWD and LWD, supporting its diagnostic usefulness.
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