Evidence map›Paper›PMID 29992033›Full record

ArticleOxford medical case reports2018

Successful eradication of leptomeningeal plasma cell disease.

Øyvind Bruserud, Bent-Are Hansen, Nils Vetti, Silje Johansen, Håkon Reikvam

Open access · goldAbstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Øyvind BruserudSection for Endocrinology, Department of Clinical Science, University of Bergen, Bergen, Norway.
Bent-Are HansenDepartment of Microbiology, Førde Hospital, Førde, Norway.
Nils VettiDepartment of Radiology, Haukeland University Hospital, Bergen, Norway.
Silje JohansenDepartment of Medicine, Haukeland University Hospital, Bergen, Norway.
Håkon ReikvamDepartment of Medicine, Haukeland University Hospital, Bergen, Norway.
Haukeland University Hospital · NOUniversity of Bergen · NOHelse Førde · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma cell leukaemia (PCL) is a rare and aggressive form of malignant monoclonal gammopathy characterized by the presence of high levels of plasma cells in peripheral blood. Central nervous system involvement of PCL has no established treatment and an extremely poor prognosis. We here present a 59-year-old male patient diagnosed with PCL, initially treated with induction chemotherapy followed by autologous peripheral blood hematopoietic stem cell transplantation. After achieving a partial response, he relapsed and presented with leptomeningeal disease. He was then successfully treated with dexamethasone, pomalidomide, and an intrathecal combination of methotrexate, methylprednisolone and cytarabine. This cleared his cerebrospinal fluid from plasma cells achieving a durable partial response.

Identifiers

PMID29992033
PMCPMC6031028
OpenAlexW2810385721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.