Evidence map›Paper›PMID 29992019›Full record

ArticleClinical kidney journal2018

Chronic kidney disease stage affects small, dense low-density lipoprotein but not glycated low-density lipoprotein in younger chronic kidney disease patients: a cross-sectional study.

Guido Filler, Sepideh Taheri, Christopher McIntyre, Connor Smith, Lakshmimathy Subramanian, Gerhard Fusch, Christoph Fusch

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02126293 (Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02126293 phase3completednot on this map

Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant

TypeinterventionalSponsorHamilton Health Sciences CorporationRan2014 to 2017Enrolled40ConditionsRenal Insufficiency, Chronic, Zinc Deficiency, Trace Element Excess, Trace Element DeficiencyArmsZinc Supplement, Repeat blood and urine tests
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Narrative Review of Carotid disease and the kidney.Annals of translational medicine · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guido FillerDepartment of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID 0000-0003-1891-6765
Sepideh TaheriDepartment of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Christopher McIntyreDepartment of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Connor SmithDepartment of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Lakshmimathy SubramanianDepartment of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Gerhard FuschDepartment of Paediatrics, McMaster University, Hamilton, ON, Canada.
Christoph FuschDepartment of Paediatrics, McMaster University, Hamilton, ON, Canada.
Western University · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall, dense low-density lipoprotein (sd-LDL) and glycated LDL (g-LDL) have been associated with cardiovascular disease (CVD) in chronic kidney disease (CKD) in patients >60 years of age. Since young adult and paediatric patients have shorter exposure to Framingham-type risk factors, our study aims to determine whether younger CKD patients exhibit the same sd-LDL and g-LDL pattern.

methodsAfter ethics board approval, this cross-sectional study was conducted at two universities with 44 patients (mean ± standard deviation age 12.6 ± 4.9, range 2-24 years) with CKD stage of 1-5. Laboratory parameters studied were Cystatin C (CysC), CysC estimated glomerular filtration rate (eGFR) (calculated from the Filler formula), sd-LDL, g-LDL and albumin. Lipid samples were measured for sd-LDL and g-LDL using ELISA. Non-linear correlation analysis was performed to determine the relationship between g-LDL, sd-LDL and eGFR. Clinical Trials Registration is at clinicaltrials.gov, NCT02126293, https://clinicaltrials.gov/ct2/show/NCT02126293.

resultsTriglycerides, but not total cholesterol and calculated LDL, were associated with CKD stages (ANOVA P = 0.0091). As in adults, sd-LDL was significantly associated with CKD stages (ANOVA P = 0.0133), CysC eGFR (

conclusionsOur study demonstrates that only triglycerides and sd-LDL were associated with CKD stages in this young cohort without confounding Framingham-type CVD risk factors. While larger studies are needed, this study suggests that lowering sd-LDL levels may be a potential target to ameliorate the long-term CVD risks in paediatric CKD patients.

Indexed as

cardiovascular riskchronic kidney diseasedisordered lipidsFramingham-type risk factorssmall dense LDLtriglycerides

Identifiers

PMID29992019
PMCPMC6007510
OpenAlexW2763266328

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.