ArticleClinical sarcoma research2018
Reversible rituximab-induced rectal Kaposi's sarcoma misdiagnosed as ulcerative colitis in a patient with HIV-negative follicular lymphoma.
Article in Clinical sarcoma research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Concurrent Kaposi Sarcoma and B-cell Lymphoma in an HIV-Negative Patient: A Case Report.Cureus · 2026Article
- Iatrogenic Kaposi Sarcoma in an HIV-Negative Patient With Immune Thrombocytopenic Purpura Treated With Rituximab and Corticosteroids: A Fatal Extracutaneous Presentation.Cancer reports (Hoboken, N.J.) · 2026Article
- Review
- Iatrogenic Kaposi's sarcoma from induction therapy for myeloma: to transplant or not to transplant?BMJ case reports · 2023Article
- Disseminated form of the Kaposi sarcoma in HIV-negative patient associated with Hodgkin's lymphoma.Oxford medical case reports · 2020Article
- [Kaposi sarcoma combined with severe ulcerative colitis: A case report and literature review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKaposi's sarcoma is a low-grade mesenchymal angioproliferative tumor, most commonly observed in immunocompromised individuals, such as HIV-infected patients. Iatrogenic Kaposi's sarcoma occurs in patients undergoing immunosuppressive therapies. Rituximab is a chimeric monoclonal antibody targeted against the pan B cell marker CD20. Because of its immunosuppressive effects through reduction of mature B-cells, it may exacerbate Kaposi's sarcoma in HIV-positive patients. Rituximab-related Kaposi's sarcomas have been previously reported in only two HIV-negative patients and were treated surgically. CASE PRESENTATION: Here, we report on a Kaposi's sarcoma that developed under rituximab treatment in a HIV-negative 55-year-old patient treated for follicular lymphoma. The lesion developed during the maintenance rituximab therapy at the rectal level with an aspect of apparent ulcerative colitis, without any cutaneous lesion. The premature stop of rituximab led to the complete regression of Kaposi's sarcoma, without any additional specific treatment.
conclusionsTo our knowledge, this is the third case of Kaposi's sarcoma diagnosed under rituximab in a HIV-negative patient, the first one at the rectal level and the first one that completely regresses after stop of rituximab. This case raises awareness of iatrogenic Kaposi's sarcoma in HIV-negative patients treated with rituximab, and further highlights the importance of immunosuppression in the pathophysiology of disease.
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