Evidence map›Paper›PMID 29991913›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2018

8-Cyclopentyl-1,3-dimethylxanthine enhances effectiveness of antidepressant in behavioral tests and modulates redox balance in the cerebral cortex of mice.

Mariola Herbet, Aleksandra Szopa, Anna Serefko, Sylwia Wośko, Monika Gawrońska-Grzywacz, Magdalena Izdebska, Iwona Piątkowska-Chmiel, Paulina Betiuk, Ewa Poleszak, Jarosław Dudka

Open access · hybridAbstract read
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mariola HerbetChair and Department of Toxicology, Medical University of Lublin, Chodźki 8, PL 20-093 Lublin, Poland.
Aleksandra SzopaDepartment of Applied Pharmacy, Medical University of Lublin, Chodźki 1, PL 20-093 Lublin, Poland.
Anna SerefkoDepartment of Applied Pharmacy, Medical University of Lublin, Chodźki 1, PL 20-093 Lublin, Poland.
Sylwia WośkoDepartment of Applied Pharmacy, Medical University of Lublin, Chodźki 1, PL 20-093 Lublin, Poland.
Monika Gawrońska-GrzywaczChair and Department of Toxicology, Medical University of Lublin, Chodźki 8, PL 20-093 Lublin, Poland.
Magdalena IzdebskaChair and Department of Toxicology, Medical University of Lublin, Chodźki 8, PL 20-093 Lublin, Poland.
Iwona Piątkowska-ChmielChair and Department of Toxicology, Medical University of Lublin, Chodźki 8, PL 20-093 Lublin, Poland.
Paulina BetiukChair and Department of Toxicology, Medical University of Lublin, Chodźki 8, PL 20-093 Lublin, Poland.
Ewa PoleszakDepartment of Applied Pharmacy, Medical University of Lublin, Chodźki 1, PL 20-093 Lublin, Poland.
Jarosław DudkaChair and Department of Toxicology, Medical University of Lublin, Chodźki 8, PL 20-093 Lublin, Poland.
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of our study was to investigate whether 8-cyclopentyl-1,3-dimethylxanthine (CPT), associated with the adenosine system, enhances the antidepressant efficacy of antidepressant. All experiments were carried out on Albino Swiss mice. Following drugs: CPT (3 mg/kg) and imipramine (15 mg/kg) were administered intraperitoneally (

Indexed as

AntidepressantCPTDepressionFSTOxidative stressTST

Identifiers

PMID29991913
PMCPMC6035324
OpenAlexW2791246017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.