Evidence map›Paper›PMID 29991878›Full record

Observational studyWorld journal of gastroenterology2018

Transforming growth factor-β and peripheral regulatory cells are negatively correlated with the overall survival of hepatocellular carcinoma.

Yang An, Song Gao, Wen-Chao Zhao, Bao-An Qiu, Nian-Xin Xia, Peng-Jun Zhang, Zhen-Ping Fan

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The Role of CD4Cells · 2026
    Review
  3. Article
  4. Article
  5. Review
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  7. Review
  8. Dairy consumption and hepatocellular carcinoma risk.Annals of translational medicine · 2021
    Review
  9. Review
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yang AnDepartment of Hepato-Biliary-Pancreatic Surgery, Navy General Hospital of Chinese People's Liberation Army, Beijing 100048, China.
Song GaoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Wen-Chao ZhaoDepartment of Hepato-Biliary-Pancreatic Surgery, Navy General Hospital of Chinese People's Liberation Army, Beijing 100048, China.
Bao-An QiuDepartment of Hepato-Biliary-Pancreatic Surgery, Navy General Hospital of Chinese People's Liberation Army, Beijing 100048, China.
Nian-Xin XiaDepartment of Hepato-Biliary-Pancreatic Surgery, Navy General Hospital of Chinese People's Liberation Army, Beijing 100048, China.
Peng-Jun ZhangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Zhen-Ping FanLiver Disease Center for Cadre Medical Care, Beijing 302 Military Hospital, Beijing 100039, China. fanzp302@126.com.
Peking University · CNPeking University Cancer Hospital · CN302 Military Hospital of China · CNPLA Navy General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo understand the cellular and molecular changes in peripheral blood that can lead to the development of hepatocellular carcinoma (HCC) and provide new methods for its diagnosis and treatment.

methodsPeripheral blood mononuclear cells were isolated from the peripheral blood of HCC patients and normal controls and then analyzed by flow cytometry. The percentage of transforming growth factor-β (TGF-β)+ regulatory cells (Tregs) in the peripheral blood was measured, and the expression of TGF-β was also determined. Then, the relationship between the changes and the 5-year survival of patients was analyzed. In addition, recombinant human TGF-β (rhTGF-β) and recombinant human interleukin-6 were added to stimulate the cultured cells, and their effects on HCC were evaluated.

resultsThe expression of TGF-β and the percentage of TGF-β+ Tregs in the peripheral blood of HCC patients increased significantly compared with normal controls. Compared with the low TGF-β expression group, the high TGF-β expression group had a significantly lower 5-year survival rate, and the same result was found in the two TGF-β+ Treg groups, suggesting that TGF-β and TGF-β+ Tregs were negatively correlated with the overall survival of the patients. In addition, rhTGF-β promoted the growth of tumor cells and induced high expression levels of IL-6, which further promoted tumor proliferation.

conclusionThe results showed that TGF-β may promote tumor growth and proliferation by inducing the production of IL-6, and TGF-β and TGF-β+ Tregs may serve as new markers for predicting a poor prognosis in HCC.

Indexed as

Biomarkers, TumorCarcinoma, HepatocellularCell Line, TumorCell ProliferationFemaleFlow CytometryForkhead Transcription FactorsHumansInterleukin-6Liver NeoplasmsMaleMiddle AgedPrimary Cell CulturePrognosisRecombinant ProteinsSurvival RateBiomarkers, TumorForkhead Transcription FactorsIL6 protein, humanInterleukin-6Recombinant ProteinsTransforming Growth Factor betaHepatocellular carcinomaInterleukin-6Peripheral blood mononuclear cellsRegulatory cellsTransforming growth factor-β

Identifiers

PMID29991878
PMCPMC6034152
OpenAlexW2878346392

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.