ArticleThe ISME journal2018
Convergent evolution of unusual complex I homologs with increased proton pumping capacity: energetic and ecological implications.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
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- Key role of hydrogen in regulating hydrogenases and the reductive TCA cycle in a thermophilic, autotrophic sulfur-reducing bacterium.Applied and environmental microbiology · 2025Article
- Potential for aerobic hydrocarbon oxidation in archaea.Nature communications · 2025Article
- Action at a distance: The remarkable coupling of COProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unusual Plastoquinones in Non-Phototrophic Nitrifying Bacteria.Environmental microbiology reports · 2025Article
- Comparative genome analysis reveals broad phylogenetic and functional diversity within the order Nitrospirales.The ISME journal · 2025Article
- A respiro-fermentative strategy to survive nanoxia in Acidobacterium capsulatum.FEMS microbiology ecology · 2024Article
- Back flux during anaerobic oxidation of butane support archaea-mediated alkanogenesis.Nature communications · 2024Article
- Cultivation and genomic characterization of novel and ubiquitous marine nitrite-oxidizing bacteria from the Nitrospirales.The ISME journal · 2023Article
- Soils and sediments host Thermoplasmata archaea encoding novel copper membrane monooxygenases (CuMMOs).The ISME journal · 2022Article
- Article
- Diverse ecophysiological adaptations of subsurface Thaumarchaeota in floodplain sediments revealed through genome-resolved metagenomics.The ISME journal · 2022Article
- Investigating the Chemolithoautotrophic and Formate Metabolism of Nitrospira moscoviensis by Constraint-Based Metabolic Modeling andmSystems · 2021Article
- Metabolic versatility of the nitrite-oxidizing bacterium Nitrospira marina and its proteomic response to oxygen-limited conditions.The ISME journal · 2021Article
- In-Situ Metatranscriptomic Analyses Reveal the Metabolic Flexibility of the Thermophilic Anoxygenic Photosynthetic BacteriumMicroorganisms · 2021Article
- Genomics, Exometabolomics, and Metabolic Probing Reveal Conserved Proteolytic Metabolism ofFrontiers in microbiology · 2021Article
- Exploring the upper pH limits of nitrite oxidation: diversity, ecophysiology, and adaptive traits of haloalkalitolerant Nitrospira.The ISME journal · 2020Article
- Insights into the Metabolism and Evolution of the GenusmSystems · 2020Article
- Article
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4 authors.
Funding
Abstract
Respiratory complex I is part of a large family of homologous enzymes that carry out the transfer of electrons between soluble cytoplasmic electron carriers and membrane-bound electron carriers. These complexes are vital bioenergetic enzymes that serve as the entry points into electron transport chains for a wide variety of microbial metabolisms, and electron transfer is coupled to proton translocation. The core complex of this enzyme is made up of 11 protein subunits, with three major proton pumping subunits. Here, we document a large number of modified complex I gene cassettes found in genome sequences from diverse cultured bacteria, shotgun metagenomics, and environmentally derived archaeal fosmids all of which encode a fourth proton pumping subunit. The incorporation of this extra subunit into a functional protein complex is supported by large amino acid insertions in the amphipathic helix that runs the length of the protein complex. Phylogenetic analyses reveal that these modified complexes appear to have arisen independently multiple times in a remarkable case of convergent molecular evolution. From an energetic perspective, we hypothesize that this modification on the canonical complex I architecture allows for the translocation of a fifth proton per reaction cycle-the physiological utility of this modified complex is discussed.
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