ArticleThe ISME journal2018
Genomes of two archaeal endosymbionts show convergent adaptations to an intracellular lifestyle.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Article
- Comparative Genomics Reveals Multipartite Genomes Undergoing Loss in the Fungal Endosymbiotic Genus Mycetohabitans.Genome biology and evolution · 2025Article
- Distinct evolutionary origins and mixed-mode transmissions of methanogenic endosymbionts are revealed in anaerobic ciliated protists.Marine life science & technology · 2025Article
- Anaerobic breviate protist survival in microcosms depends on microbiome metabolic function.The ISME journal · 2025Article
- Genetic potential for aerobic respiration and denitrification in globally distributed respiratory endosymbionts.Nature communications · 2024Article
- The parasitic lifestyle of an archaeal symbiont.Nature communications · 2024Article
- Symbionts of Ciliates and Ciliates as Symbionts.Indian journal of microbiology · 2024Review
- Methanogenic symbionts of anaerobic ciliates are host and habitat specific.The ISME journal · 2024Article
- Divergent marine anaerobic ciliates harbor closely related Methanocorpusculum endosymbionts.The ISME journal · 2024Article
- Facultative endosymbiosis between cellulolytic protists and methanogenic archaea in the gut of the Formosan termiteISME communications · 2024Article
- The energy metabolism of Balantidium polyvacuolum inhabiting the hindgut of Xenocypris davidi.BMC genomics · 2023Article
- Gut microbiota of an Amazonian fish in a heterogeneous riverscape: integrating genotype, environment, and parasitic infections.Microbiology spectrum · 2023Article
- Diversity and taxonomic revision of methanogens and other archaea in the intestinal tract of terrestrial arthropods.Frontiers in microbiology · 2023Article
- Bacterial symbiosis in ciliates (Alveolata, Ciliophora): Roads traveled and those still to be taken.The Journal of eukaryotic microbiology · 2022Review
- Characterization of metagenome-assembled genomes of two endo-archaea ofFrontiers in microbiomes · 2022Article
- Comparative genomic analysis of Methanimicrococcus blatticola provides insights into host adaptation in archaea and the evolution of methanogenesis.ISME communications · 2021Article
- Comparative Genomics Provides Insights into the Genetic Diversity and Evolution of the DPANN Superphylum.mSystems · 2021Article
- Archaeal Communities: The Microbial Phylogenomic Frontier.Frontiers in genetics · 2021Review
- The host-associated archaeome.Nature reviews. Microbiology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endosymbiosis is a widespread phenomenon in the microbial world and can be based on diverse interactions between endosymbiont and host cell. The vast majority of the known endosymbiotic interactions involve bacteria that have invaded eukaryotic host cells. However, methanogenic archaea have been found to thrive in anaerobic, hydrogenosome-containing protists and it was suggested that this symbiosis is based on the transfer of hydrogen. Here, we used culture-independent genomics approaches to sequence the genomes of two distantly related methanogenic endosymbionts that have been acquired in two independent events by closely related anaerobic ciliate hosts Nyctotherus ovalis and Metopus contortus, respectively. The sequences obtained were then validated as originating from the ciliate endosymbionts by in situ probing experiments. Comparative analyses of these genomes and their closest free-living counterparts reveal that the genomes of both endosymbionts are in an early stage of adaptation towards endosymbiosis as evidenced by the large number of genes undergoing pseudogenization. For instance, the observed loss of genes involved in amino acid biosynthesis in both endosymbiont genomes indicates that the endosymbionts rely on their hosts for obtaining several essential nutrients. Furthermore, the endosymbionts appear to have gained significant amounts of genes of potentially secreted proteins, providing targets for future studies aiming to elucidate possible mechanisms underpinning host-interactions. Altogether, our results provide the first genomic insights into prokaryotic endosymbioses from the archaeal domain of life.
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