ArticleScientific reports2018
Time-related association between fluid balance and mortality in sepsis patients: interaction between fluid balance and haemodynamics.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Fluid balance and mortality in adult ICU patients with sepsis or septic shock: a systematic review and meta-analysis of observational studies.BMC anesthesiology · 2025Pooled it
- Time-Dependent Fluid Accumulation Index for Phase-Specific Risk Stratification in Septic Shock with Heart Failure.Current medical science · 2026Article
- Association of fluid balance trajectories and cumulative fluid balance with in-hospital mortality in patients with acute pancreatitis.Frontiers in medicine · 2026Article
- Associations between fluid overload and outcomes in critically ill patients with acute kidney injury: a retrospective observational study.Scientific reports · 2023Observational
- A system theory based digital model for predicting the cumulative fluid balance course in intensive care patients.Frontiers in physiology · 2023Article
- Evaluating the Impact of Positive Fluid Balance on Mortality and Length of Stay in Septic Shock Patients.Cureus · 2022Article
- Association of Fluid Management With Mortality of Sepsis Patients With Congestive Heart Failure: A Retrospective Cohort Study.Frontiers in medicine · 2022Article
- Low fluid intake volume during the first 24 h and persistent negative fluid balance from the second day are associated with favorable prognosis for patients with sepsis.Experimental and therapeutic medicine · 2021Article
- Association of fluid balance with mortality in sepsis is modified by admission hemoglobin levels: A large database study.PloS one · 2021Article
- Sepsis-Pathophysiology and Therapeutic Concepts.Frontiers in medicine · 2021Review
- Observational
- Effect of initial infusion rates of fluid resuscitation on outcomes in patients with septic shock: a historical cohort study.Critical care (London, England) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the time-related association between cumulative fluid balance (FB) and mortality. Data were extracted from the Medical Information Mart for Intensive Care (MIMIC) III. FB data on 8584 patients at the first (FB-fir24hr) and second (FB-sec24hr) 24 hours after intensive care unit admission were analysed. Compared to the combination of FB-fir24hr ≤ 0 and FB-sec24 hr ≤ 0, the combination of FB-fir24hr > 0 and FB-sec24hr ≤ 0 had significantly higher FB, with an insignificant odds ratio (OR) for mortality. However, the mortality ORs of two other combinations (FB-fir24hr ≤ 0 and FB-sec24hr > 0; FB-fir24hr > 0 and FB-sec24hr > 0) were significantly high. Furthermore, multivariable logistic analysis showed a significant stepwise increase ORs for mortality with increasing FB-sec24hr quartiles, with no significant increase in FB-fir24hr quartiles aside from quartile 4. In patients with negative FB, a stepwise decrease in mortality ORs with increasing FB-sec24hr quartiles was found with no significant difference in FB-fir24hr quartiles. In conclusion, the positive FB during the second but not the first 24 hours was associated with increased mortality in sepsis. Achieving more negative FB was associated with decreased mortality only in the second 24 hours.
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