Evidence map›Paper›PMID 29991748›Full record

ArticleScientific reports2018

Diffusion weighted MRI as an early predictor of tumor response to hypofractionated stereotactic boost for prostate cancer.

David Pasquier, Abderraouf Hadj Henni, Alexandre Escande, Emmanuelle Tresch, Nick Reynaert, Olivier Colot, Eric Lartigau, Nacim Betrouni

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David PasquierAcademic Department of Radiation Oncology, Oscar Lambret Comprehensive Cancer Center, Lille, France. d-pasquier@o-lambret.fr.ORCID 0000-0001-6019-7309
Abderraouf Hadj HenniINSERM, U1171, University of Lille, Lille, France.
Alexandre EscandeAcademic Department of Radiation Oncology, Oscar Lambret Comprehensive Cancer Center, Lille, France.
Emmanuelle TreschDepartment of Biostatistics, Oscar Lambret Comprehensive Cancer Center, Lille, France.
Nick ReynaertDepartment of Medical Physics, Oscar Lambret Comprehensive Cancer Center, Lille, France.
Olivier ColotCRIStAL laboratory, UMR CNRS 9189, University Lille 1, Villeneuve d'Ascq, France.
Eric LartigauAcademic Department of Radiation Oncology, Oscar Lambret Comprehensive Cancer Center, Lille, France.
Nacim BetrouniINSERM, U1171, University of Lille, Lille, France.
Centre National de la Recherche Scientifique · FRCentre Oscar Lambret · FRInserm · FR

Funding

Institut National Du Cancer (French National Cancer Institute) PHRC-K 2009
6 · The paper itself

Abstract

We evaluated the feasibility of using the kinetic of diffusion-weighted MRI (DWI) and the normalized apparent coefficient diffusion (ADC) map value as an early biomarker in patients treated by external beam radiotherapy (EBRT). Twelve patients were included within the frame of a multicenter phase II trial and treated for intermediate risk prostate cancer (PCa). Multiparametric MRI was performed before treatment (M0) and every 6 months until M24. Association between nADC and PSA or PSA kinetic was evaluated using the test of nullity of the Spearman correlation coefficient. The median rates of PSA at the time of diagnosis, two years and four years after EBRT were 9.29 ng/ml (range from 5.26 to 17.67), 0.68 ng/ml (0.07-2.7), 0.47 ng/ml (0.09-1.39), respectively. Median nADC increased from 1.14 × 10

Indexed as

AgedDiffusion Magnetic Resonance ImagingHumansImaging, Three-DimensionalMaleMiddle AgedProstateProstate-Specific AntigenProstatic NeoplasmsRadiation Dose HypofractionationProstate-Specific Antigen

Identifiers

PMID29991748
PMCPMC6039515
OpenAlexW2811455089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.