Evidence map›Paper›PMID 29991742›Full record

ArticleCell death & disease2018

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.

Zhi-Qiang Yao, Xin Zhang, Yongqi Zhen, Xu-Ying He, Shuangmei Zhao, Xi-Feng Li, Bo Yang, Feng Gao, Fu-You Guo, Leilei Fu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Review
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  5. Article
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  10. Mechanism and regulation of mitophagy in liver diseases: a review.Frontiers in cell and developmental biology · 2025
    Review
  11. Article
  12. Review
  13. Review
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  17. Article
  18. Does Selection for Longevity inInternational journal of molecular sciences · 2024
    Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhi-Qiang YaoThe National Key Clinical Specialty, The Engineering Technology Research Center of Education of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Xin ZhangThe National Key Clinical Specialty, The Engineering Technology Research Center of Education of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Yongqi ZhenSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Xu-Ying HeThe National Key Clinical Specialty, The Engineering Technology Research Center of Education of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Shuangmei ZhaoSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Xi-Feng LiThe National Key Clinical Specialty, The Engineering Technology Research Center of Education of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Bo YangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou, 450052, China.
Feng GaoSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Fu-You GuoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou, 450052, China.
Leilei FuSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. leilei_fu@163.com.
Xian-Zhi LiuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou, 450052, China. liuxianzhi2@sina.com.
Chuan-Zhi DuanThe National Key Clinical Specialty, The Engineering Technology Research Center of Education of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. Doctor_duanzj@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sirtuin-1 (SIRT1), the mammalian ortholog of yeast Sir2p, is well known to be a highly conserved NAD

Indexed as

AnimalsAntineoplastic AgentsApoptosisAutophagyCell Line, TumorFemaleGlioblastomaHumansMiceMice, Inbred BALB CProfilinsProtein KinasesProteomicsPTEN-Induced Putative KinaseSirtuin 1Ubiquitin-Protein LigasesAntineoplastic Agentsparkin proteinProfilinsProtein KinasesPTEN-Induced Putative KinaseSirtuin 1Ubiquitin-Protein Ligases

Identifiers

PMID29991742
PMCPMC6039470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.