Evidence map›Paper›PMID 29991721›Full record

ArticleScientific reports2018

Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K

O Rauh, U P Hansen, D D Scheub, G Thiel, I Schroeder

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Similarity of the ion occupations of KChannels (Austin, Tex.) · 2026
    Article
  2. Article
  3. Modular architecture of KEMBO reports · 2025
    Review
  4. Do selectivity filter carbonyls in KJournal of structural biology: X · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Asymmetric Interplay Between KFrontiers in physiology · 2021
    Article
  14. Article
  15. Article
  16. A Functional KViruses · 2020
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

O RauhPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
U P HansenDepartment of Structural Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
D D ScheubPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
G ThielPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
I SchroederPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany. schroeder@bio.tu-darmstadt.de.
Technical University of Darmstadt · DEKiel University · DE

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) HA 712/14-3Deutsche Forschungsgemeinschaft (German Research Foundation) SCHR 1467/1-1EC | European Research Council (ERC) 695078 (NoMAGIC)
6 · The paper itself

Abstract

Many potassium channels show voltage-dependent gating without a dedicated voltage sensor domain. This is not fully understood yet, but often explained by voltage-induced changes of ion occupation in the five distinct K

Indexed as

Binding SitesIon Channel GatingKCNQ1 Potassium ChannelKineticsPotassiumPotassium ChannelsViral ProteinsKCNQ1 Potassium ChannelKcv potassium channel, Chlorella virusPotassiumPotassium ChannelsViral Proteins

Identifiers

PMID29991721
PMCPMC6039446
OpenAlexW2810576679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.