ReviewJournal of human hypertension2018
Impact of SPRINT results on hypertension guidelines: implications for "frail" elderly patients.
Review in Journal of human hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is Blood Pressure Lowering in the Very Elderly With Previous Stroke Associated With a Higher Risk of Adverse Events?Journal of the American Heart Association · 2021Pooled it
- Sex-specific All-cause Mortality is Associated with Adiposity in the Malaysian Elders Longitudinal Research (MELoR) Study.Annals of geriatric medicine and research · 2025Article
- Does the frailty index applied to randomised controlled trials really measure frailty?Age and ageing · 2025Article
- Review
- A scoping review of the measurement and analysis of frailty in randomised controlled trials.Age and ageing · 2024Article
- Hypertension in the older person: is age just a number?Internal medicine journal · 2022Review
- Management of Hypertension in the Elderly and Frail Patient.Drugs & aging · 2022Article
- A clinical algorithm to determine target blood pressure in the elderly: evidence and limitations from a clinical perspective.Clinical hypertension · 2022Review
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Observed and expected serious adverse event rates in randomised clinical trials for hypertension: an observational study comparing trials that do and do not focus on older people.The lancet. Healthy longevity · 2021Observational
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Frailty and hypertension in older adults: current understanding and future perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Intensive blood pressure lowering: a practical review.Clinical hypertension · 2020Review
- Blood Pressure Targets for Older Patients-Do Advanced Age and Frailty Really Not Matter?Canadian geriatrics journal : CGJ · 2020Article
- Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.Journal of the American Geriatrics Society · 2019Article
- Frailty in Chinese older adults with hypertension: Prevalence, associated factors, and prediction for long-term mortality.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last years, guidelines for the treatment of hypertension recommended individualized blood pressure goals for geriatric population because of elderly susceptibility to adverse outcomes and higher mortality rate deriving from the excessive blood pressure lowering, especially in "frail" elderly. Recent findings from the SPRINT study, which demonstrated that intensive blood pressure lowering was associated with lower rates of cardiovascular events and mortality in both hypertensive fit and frail elderly subjects compared to standard treatment, heavily influenced the recent US guidelines. In SPRINT sub-study analysis of adults aged ≥75 years, the most controversial issue appears the method of blood pressure measurement, the selection of patients and related-frailty degree that appears to be very light. Accordingly, it has been described that light frailty is related to good outcomes in older adults. SPRINT findings in "frail elderly patients" cannot be applied to the clinical practice because this condition has been clearly under-estimated. Thus, frailty status should be routinely and correctly quantified in order to identify the frailty degree and to find the best harms-benefits balance of antihypertensive drug treatment in frail older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.