Evidence map›Paper›PMID 29991598›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

Efrat Katz, Ohad Stoler, Anja Scheller, Yana Khrapunsky, Sandra Goebbels, Frank Kirchhoff, Michael J Gutnick, Fred Wolf, Ilya A Fleidervish

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  7. Neurologist's Black Swan: Molecular Basis of Prenatal Seizures.International journal of molecular sciences · 2025
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  19. Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Efrat KatzKoret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Ohad StolerDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Anja SchellerDepartment of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine, University of Saarland, 66421 Homburg, Germany.ORCID 0000-0001-8955-2634
Yana KhrapunskyDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Sandra GoebbelsDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Frank KirchhoffDepartment of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine, University of Saarland, 66421 Homburg, Germany.
Michael J GutnickKoret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 7610001, Israel.ORCID 0000-0003-2564-5094
Fred WolfResearch Group of Theoretical Neurophysics, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Ilya A FleidervishDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel; ilya@bgu.ac.il.
Ben-Gurion University of the Negev · ILHebrew University of Jerusalem · ILSaarland University · DEBernstein Center for Computational Neuroscience Göttingen · DEMax Planck Institute of Experimental Medicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neocortical pyramidal neurons express several distinct subtypes of voltage-gated Na

Indexed as

Action PotentialsAnimalsAxonsGene DeletionMiceMice, TransgenicNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelNeocortexPyramidal CellsNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseaction potentialaxon initial segmentconditional knockoutNa+ fluxNav1.6 channel

Identifiers

PMID29991598
PMCPMC6065046
OpenAlexW2852401257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.