Evidence map›Paper›PMID 29991594›Full record

ArticleThe Journal of biological chemistry2018

Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run.

Sean M Quinn, Daniel P Howsmon, Juergen Hahn, Susan P Gilbert

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sean M QuinnFrom the Departments of Biological Sciences.
Daniel P HowsmonChemical and Biological Engineering, and.ORCID 0000-0002-7177-1342
Juergen HahnChemical and Biological Engineering, and hahnj@rpi.edu.ORCID 0000-0002-1078-4203
Susan P GilbertFrom the Departments of Biological Sciences, sgilbert@rpi.edu.ORCID 0000-0002-7823-3774
Rensselaer Polytechnic Institute · US

Funding

Mechanistic Analysis of Microtubule Based MotorsR37GM054141 · NIGMS · RENSSELAER POLYTECHNIC INSTITUTE · PI GILBERT, SUSAN P. · 2013 to 2022
$4.4M
Modeling and Analysis of the Role of Microbiota Metabolites in T-Cell DifferentiationR01AI110642 · NIAID · TEXAS ENGINEERING EXPERIMENT STATION · PI ALANIZ, ROBERT CHRISTOPHER, HAHN, JUERGEN · 2015 to 2019
$2.0M
NIAID NIH HHS R01 AI110642NIGMS NIH HHS R37 GM054141
6 · The paper itself

Abstract

Heterodimeric KIF3AC and KIF3AB, two members of the mammalian kinesin-2 family, generate force for microtubule plus end-directed cargo transport. However, the advantage of heterodimeric kinesins over homodimeric ones is not well-understood. We showed previously that microtubule association for entry into a processive run was similar in rate for KIF3AC and KIF3AB at ∼7.0 μm

Indexed as

Adenosine DiphosphateAdenosine TriphosphateAnimalsKinesinsMiceMicrotubule-Associated ProteinsMicrotubulesProtein MultimerizationAdenosine DiphosphateAdenosine TriphosphateKif3a protein, mouseKif3b protein, mouseKif3c protein, mouseKinesinsMicrotubule-Associated ProteinsATPaseciliogenesiscomputational biologyintracellular traffickingintraflagellar transportmathematical modelingmicrotubuleneuronpre-steady-state kineticsprocessivity

Identifiers

PMID29991594
PMCPMC6120217
OpenAlexW2873176665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.