Evidence map›Paper›PMID 29991491›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

ABCC6 Deficiency Promotes Development of Randall Plaque.

Emmanuel Letavernier, Gilles Kauffenstein, Léa Huguet, Nastassia Navasiolava, Elise Bouderlique, Ellie Tang, Léa Delaitre, Dominique Bazin, Marta de Frutos, Clément Gay and 9 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
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  4. The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026
    Review
  5. Article
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  8. Oral pyrophosphate protects Abcc6Journal of molecular medicine (Berlin, Germany) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Emmanuel LetavernierUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France; emmanuel.letavernier@aphp.fr.
Gilles KauffensteinInstitut des maladies mitochondriales, du coeur et des vaisseaux-MITOVASC, Centre National de la Recherche Scientifique 6015, Institut National de la Santé et de la Recherche Médicale U1083, Angers University, Angers, France.ORCID 0000-0003-4994-8305
Léa HuguetUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Nastassia NavasiolavaDepartment of Dermatology, PseudoXanthoma Elasticum Consultation center, Reference Center for rare skin diseases, Angers University Hospital, France.
Elise BouderliqueUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Ellie TangUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Léa DelaitreDepartment of Dermatology, PseudoXanthoma Elasticum Consultation center, Reference Center for rare skin diseases, Angers University Hospital, France.
Dominique BazinUnité Mixte de Recherche 8502, Laboratoire de Physique des Solides, Centre National de la Recherche Scientifique, Université Paris Sud XI, Orsay, France.
Marta de FrutosUnité Mixte de Recherche 8502, Laboratoire de Physique des Solides, Centre National de la Recherche Scientifique, Université Paris Sud XI, Orsay, France.ORCID 0000-0002-9053-1723
Clément GayUnité Mixte de Recherche 8502, Laboratoire de Physique des Solides, Centre National de la Recherche Scientifique, Université Paris Sud XI, Orsay, France.ORCID 0000-0001-5438-6162
Joëlle PerezUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Marie-Christine VerpontUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Jean-Philippe HaymannUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Viola PomoziDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii; and.
Janna ZollDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii; and.
Olivier Le SauxDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii; and.
Michel DaudonUnité Mixte de Recherche S 1155, Sorbonne Universités, Université Pierre et Marie Curie-Paris 06, Paris, France.
Georges LeftheriotisDepartment of Physiology and Molecular Medicine, Unité Mixte de Recherche 7370, Centre National de la Recherche Scientifique, University of Nice, Nice, France.
Ludovic MartinInstitut des maladies mitochondriales, du coeur et des vaisseaux-MITOVASC, Centre National de la Recherche Scientifique 6015, Institut National de la Santé et de la Recherche Médicale U1083, Angers University, Angers, France.
Inserm · FRUniversité Paris-Sud · FRUniversity of Hawaiʻi at Mānoa · USUniversité d'Angers · FRCentre National de la Recherche Scientifique · FR

Funding

TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Kathryn Jaques Schunke · 2017 to 2026
$21.5M
The role of ABCC6 in chronic and acute cardiovascular mineralizationR01HL108249 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI BOISVERT, WILLIAM A, LE SAUX, OLIVIER · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL108249NIGMS NIH HHS P20 GM113134
6 · The paper itself

Abstract

backgroundPseudoxanthoma elasticum (PXE) is a genetic disease caused by mutations in the

methodsWe conducted a retrospective study in a large cohort of patients with PXE and analyzed urine samples and kidneys from

resultsAmong 113 patients with PXE, 45 (40%) had a past medical history of kidney stones. Five of six computed tomography scans performed showed evidence of massive papillary calcifications (Randall plaques).

conclusionsThe frequency of kidney stones and probably, Randall plaque is extremely high in patients with PXE, and

Indexed as

AnimalsATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersBiopsy, NeedleCalcinosisCohort StudiesDisease Models, AnimalFemaleHumansImmunohistochemistryIncidenceKidney CalculiMaleMiceMice, Inbred C57BLPrognosisABCC6 protein, humanAbcc6 protein, mouseATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette Transporterscalciumgenetic renal diseasemineral metabolism

Identifiers

PMID29991491
PMCPMC6115671
OpenAlexW2826535694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.