Evidence map›Paper›PMID 29991395›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2018

Older age at first tuberculosis diagnosis is associated with tuberculosis recurrence in HIV-negative persons.

Y F van der Heijden, F Karim, T Chinappa, G Mufamadi, L Zako, B E Shepherd, F Maruri, M-Y S Moosa, T R Sterling, A S Pym

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Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Y F van der HeijdenVanderbilt Tuberculosis Center, Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
F KarimVanderbilt Tuberculosis Center, Africa Health Research Institute, Durban.
T ChinappaVanderbilt Tuberculosis Center, eThekwini Municipality, Durban, South Africa.
G MufamadiVanderbilt Tuberculosis Center, eThekwini Municipality, Durban, South Africa.
L ZakoVanderbilt Tuberculosis Center, eThekwini Municipality, Durban, South Africa.
B E ShepherdVanderbilt Tuberculosis Center, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
F MaruriVanderbilt Tuberculosis Center, Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
M-Y S MoosaVanderbilt Tuberculosis Center, Department of Infectious Diseases, Division of Internal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
T R SterlingVanderbilt Tuberculosis Center, Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
A S PymVanderbilt Tuberculosis Center, Africa Health Research Institute, Durban.
Vanderbilt University · USeThekwini Municipality · ZAAfrica Health Research Institute · ZAUniversity of KwaZulu-Natal · ZA

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Chandravanu Dash · 2015 to 2026
$27.5M
Fluoroquinolone resistance in patients with multidrug-resistant tuberculosisK08AI106420 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VAN DER HEIJDEN, YURI F. · 2014 to 2018
$848k
NIAID NIH HHS K08 AI106420NIAID NIH HHS P30 AI110527NIAID NIH HHS U01 AI069924
6 · The paper itself

Abstract

settingTuberculosis (TB) clinic in Durban, South Africa.

objectiveTo assess the factors associated with TB recurrence among human immunodeficiency virus (HIV) negative adults and children.

designWe conducted a retrospective longitudinal study from January 2000 to December 2012. We defined recurrence as a TB episode occurring within the study period after treatment completion or cure of a previous episode. We used a multivariable Poisson regression model to assess the factors associated with the number of recurrences among HIV-negative patients.

resultsAmong 17 941 patients with known HIV status, 3653 (20%) were HIV-negative; of these, 235 (6%) had one recurrence, 21 (1%) had two recurrences and 4 (0.1%) had three recurrences. The median follow-up time from the end of treatment for the first episode was 3.0 years (interquartile range 1.9-4.2). Age at the first TB episode was significantly associated with the number of TB recurrences: younger patients had the lowest rate of recurrence, with a steady increase in rates until age 40 years, after which rates stabilized.

conclusionsTB recurrence rates among HIV-negative patients were higher at increased age at the first TB episode. Further translational studies are needed to clarify the factors that drive multiple TB recurrences in older age, including impaired immunity, the results of which have implications for TB vaccine development.

Indexed as

Age FactorsImmunosenescenceAdultAntitubercular AgentsFemaleHIV SeronegativityHumansLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisRecurrenceRegression AnalysisRetrospective StudiesRisk FactorsSouth AfricaAntitubercular Agents

Identifiers

PMID29991395
PMCPMC6064608
OpenAlexW2849994087

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.