Evidence map›Paper›PMID 29991383›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2018

Gonorrhoea treatment failure caused by a

David W Eyre, Nicholas D Sanderson, Emily Lord, Natasha Regisford-Reimmer, Kevin Chau, Leanne Barker, Markus Morgan, Robert Newnham, Daniel Golparian, Magnus Unemo and 7 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 4 pooled it
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 4 syntheses or guidelines pooled it, 361 citations in OpenAlex.

  1. Pooled it
  2. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. An antibody-drug conjugate active against antibiotic-resistantProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Rapid detection of ceftriaxone-resistantMicrobiology spectrum · 2026
    Article
  9. Article
  10. Antimicrobial resistance crisis in STIs: Gonorrhea andNew microbes and new infections · 2026
    Review
  11. Extensively drug-resistant (XDR)Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  12. Article
  13. Review
  14. Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  15. Repurposing epetraborole to combatAntimicrobial agents and chemotherapy · 2026
    Article
  16. Article
  17. Article
  18. Epidemiology and infection · 2026
    Article
  19. Article
  20. Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

David W EyreBig Data Institute, University of Oxford, Oxford, United Kingdom.
Nicholas D SandersonNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Emily LordOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Natasha Regisford-ReimmerOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Kevin ChauNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Leanne BarkerNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Markus MorganOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Robert NewnhamOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Daniel GolparianWHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Örebro University Hospital, Örebro, Sweden.
Magnus UnemoWHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Örebro University Hospital, Örebro, Sweden.
Derrick W CrookNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Tim Ea PetoNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Gwenda HughesNational Infection Service, Public Health England, Colindale, United Kingdom.
Michelle J ColeNational Infection Service, Public Health England, Colindale, United Kingdom.
Helen FiferNational Infection Service, Public Health England, Colindale, United Kingdom.
Anne EdwardsOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Monique I AnderssonOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Oxford University Hospitals NHS Trust · GBPublic Health England · GBUniversity of Oxford · GBÖrebro University Hospital · SEOpen Data Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

Indexed as

AdultAnti-Bacterial AgentsAzithromycinCeftriaxoneDoxycyclineDrug Resistance, BacterialEnglandGonorrheaHumansMaleMicrobial Sensitivity TestsNeisseria gonorrhoeaeSequence AnalysisSpectinomycinThailandTravelAnti-Bacterial AgentsAzithromycinCeftriaxoneDoxycyclineSpectinomycinantimicrobial resistanceantimicrobial treatment, whole-genome sequencinggonorrhoeatreatment failure

Identifiers

PMID29991383
PMCPMC6152157
OpenAlexW2837231096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.