Evidence map›Paper›PMID 29991314›Full record

ArticleJournal of geriatric psychiatry and neurology2018

Whole-Genome mRNA Gene Expression Differs Between Patients With and Without Delirium.

Katrina Kalantar, Sara C LaHue, Joseph L DeRisi, Hannah A Sample, Caitlin A Contag, Scott A Josephson, Michael R Wilson, Vanja C Douglas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric psychiatry and neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Katrina Kalantar1 Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Sara C LaHue2 Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Joseph L DeRisi1 Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Hannah A Sample1 Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Caitlin A Contag4 School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Scott A Josephson2 Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Michael R Wilson2 Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Vanja C Douglas2 Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
NCATS NIH HHS KL2 TR000143
6 · The paper itself

Abstract

objectiveTo identify differences in gene expression between patients with in-hospital delirium from a known etiology (urinary tract infection [UTI]) and patients with delirium from an unknown etiology, as well as from nondelirious patients.

methodsThirty patients with delirium (8 with UTI) and 21 nondelirious patients (11 with UTI) were included in this prospective case-control study. Transcriptomic profiles from messenger RNA sequencing of peripheral blood were analyzed for gene expression and disease-specific pathway enrichment patterns, correcting for systemic inflammatory response syndrome. Genes and pathways with significant differential activity based on Fisher exact test ( P < .05, |Z score| >2) are reported.

resultsPatients with delirium with UTI, compared to patients with delirium without UTI, exhibited significant activation of interferon signaling, upstream cytokines, and transcription regulators, as well as significant inhibition of actin cytoskeleton, integrin, paxillin, glioma invasiveness signaling, and upstream growth factors. All patients with delirium, compared to nondelirious patients, had significant complement system activation. Among patients with delirium without UTI, compared to nondelirious patients without UTI, there was significant activation of elF4 and p7056 K signaling.

conclusionsDifferences exist in gene expression between delirious patients due to UTI presence, as well as due to the presence of delirium alone. Transcriptional profiling may help develop etiology-specific biomarkers for patients with delirium.

Indexed as

AgedCase-Control StudiesDeliriumFemaleGene ExpressionHumansMaleProspective StudiesRNA, MessengerUrinary Tract InfectionsRNA, MessengerdeliriumRNA sequencingtranscriptomeurinary tract infection

Identifiers

PMID29991314
PMCPMC6817976
OpenAlexW2812763442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.