Evidence map›Paper›PMID 29990584›Full record

Trial reportNeuroImage2018

Impact of short- and long-term mindfulness meditation training on amygdala reactivity to emotional stimuli.

Tammi R A Kral, Brianna S Schuyler, Jeanette A Mumford, Melissa A Rosenkranz, Antoine Lutz, Richard J Davidson

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  14. Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tammi R A KralCenter for Healthy Minds, University of Wisconsin - Madison, 625 W. Washington Avenue, Madison, WI, 53703, USA; Department of Psychology, University of Wisconsin - Madison, 1202 W. Johnson Street, Madison, WI, 53706, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison, 1500 Highland Avenue, Madison, WI, 53705, USA.
Brianna S SchuylerCenter for Healthy Minds, University of Wisconsin - Madison, 625 W. Washington Avenue, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison, 1500 Highland Avenue, Madison, WI, 53705, USA.
Jeanette A MumfordCenter for Healthy Minds, University of Wisconsin - Madison, 625 W. Washington Avenue, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison, 1500 Highland Avenue, Madison, WI, 53705, USA.
Melissa A RosenkranzCenter for Healthy Minds, University of Wisconsin - Madison, 625 W. Washington Avenue, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison, 1500 Highland Avenue, Madison, WI, 53705, USA.
Antoine LutzCenter for Healthy Minds, University of Wisconsin - Madison, 625 W. Washington Avenue, Madison, WI, 53703, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison, 1500 Highland Avenue, Madison, WI, 53705, USA; Lyon Neuroscience Research Center, Lyon 1 University, Lyon, France.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin - Madison, 625 W. Washington Avenue, Madison, WI, 53703, USA; Department of Psychology, University of Wisconsin - Madison, 1202 W. Johnson Street, Madison, WI, 53706, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison, 1500 Highland Avenue, Madison, WI, 53705, USA; Department of Psychiatry, University of Wisconsin - Madison, 6001 Research Park Boulevard, Madison, WI, 53719, USA. Electronic address: rjdavids@wisc.edu.

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
Wisconsin Center for the Neuroscience and Psychophysiology of MeditationP01AT004952 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 2008 to 2018
$14.7M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
STRESS EXPOSURE, HPA ACTIVITY AND RISK FOR ADOLESCENT INTERNALIZING DISORDERSP50MH084051 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2008 to 2012
$9.6M
Neural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6M
NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
NCCIH NIH HHS P01 AT004952NICHD NIH HHS P30 HD003352NIGMS NIH HHS T32 GM007507NIMH NIH HHS P50 MH084051NIMH NIH HHS R01 MH043454NIMH NIH HHS T32 MH018931
6 · The paper itself

Abstract

Meditation training can improve mood and emotion regulation, yet the neural mechanisms of these affective changes have yet to be fully elucidated. We evaluated the impact of long- and short-term mindfulness meditation training on the amygdala response to emotional pictures in a healthy, non-clinical population of adults using blood-oxygen level dependent functional magnetic resonance imaging. Long-term meditators (N = 30, 16 female) had 9081 h of lifetime practice on average, primarily in mindfulness meditation. Short-term training consisted of an 8-week Mindfulness- Based Stress Reduction course (N = 32, 22 female), which was compared to an active control condition (N = 35, 19 female) in a randomized controlled trial. Meditation training was associated with less amygdala reactivity to positive pictures relative to controls, but there were no group differences in response to negative pictures. Reductions in reactivity to negative stimuli may require more practice experience or concentrated practice, as hours of retreat practice in long-term meditators was associated with lower amygdala reactivity to negative pictures - yet we did not see this relationship for practice time with MBSR. Short-term training, compared to the control intervention, also led to increased functional connectivity between the amygdala and a region implicated in emotion regulation - ventromedial prefrontal cortex (VMPFC) - during affective pictures. Thus, meditation training may improve affective responding through reduced amygdala reactivity, and heightened amygdala-VMPFC connectivity during affective stimuli may reflect a potential mechanism by which MBSR exerts salutary effects on emotion regulation ability.

Indexed as

MeditationMindfulnessAdultAmygdalaConnectomeEmotionsFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMiddle AgedPattern Recognition, VisualPrefrontal CortexTime FactorsAmygdalaConnectivityEmotion regulationMeditationMindfulnessPrefrontal cortex

Identifiers

PMID29990584
PMCPMC6671286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.