ArticlePloS one2018
Isolation and purification of antibacterial compound from Streptomyces levis collected from soil sample of north India.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Antimicrobial potential of actinomycetes from high altitude Nepalese soils.Scientific reports · 2025Article
- Purification and characterization of an antimicrobial compound against drug-resistant MRSA and VRE produced by Streptomyces levis strain HFM-2.Scientific reports · 2025Article
- Combatting Sugar Beet Root Rot:Plants (Basel, Switzerland) · 2024Article
- The Influence of Hydrodynamic Conditions in a Laboratory-Scale Bioreactor onMicroorganisms · 2022Article
- Potential Bioactive Compounds from Marine Streptomyces sp. and Their In Vitro Antibiofilm and Antibacterial Activities Against Antimicrobial-Resistant Clinical Pathogens.Applied biochemistry and biotechnology · 2022Article
- Bioleaching of Heavy Metals by Streptomyces avermitilis - BBA4 Isolate from Coal Mine Soil of Tamil Nadu.Current microbiology · 2022Article
- Purification and Characterization of Bioactive Metabolite fromBioMed research international · 2022Article
- Antimicrobial and antinematicidal metabolites fromSaudi journal of biological sciences · 2020Article
- Optimization of Fermentation Conditions to Enhance Cytotoxic Metabolites Production byAvicenna journal of medical biotechnologyArticle
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Authors and funding
8 authors.
Funding
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Abstract
During the screening programme for microbial cultures producing antimicrobial agents, an active microbial strain of Streptomyces was isolated from the agricultural soil of Narnaul, Haryana India. Physiological, biochemical characteristics and 16S ribosomal RNA sequence homology studies revealed that it was similar to Streptomyces levis (sequence similarity 100%). The microbial strain was submitted to Genomebio Technologies Pvt. Ltd., Pune, Maharashtra, India under Accession No. EU124569. The isolated strain was found to produce extracellular active compound showing strong antimicrobial activity against Klebsiella pneumoniae MTCC 109, Pseudomonas aeruginosa MTCC 741 and Staphylococcus aureus MTCC 96. The antibacterial compound was successfully isolated and purified. Structure elucidation of antibacterial metabolite with EI-MS/ HRMS showed molecular ion peak at m/z 686 [M+H]+. Whereas, elemental analysis of the said compound showed C = 61.31, H = 8.61, N = 2.04 and O = 28.02, and indicated a molecular formula of C35H59NO12. The presence of 'chromone' nucleus in the compound's chemical structure was confirmed by using 1HNMR studies. The present study reports the purification of potential antibacterial compound from Streptomyces levis isolated from the unexplored soil of north India and warrants for further characterization of this potential compound for optimum utilization for antimicrobial purposes.
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