ArticlePloS one2018
Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 96 citations in OpenAlex.
- Trial
- Taurine reduces intracellular glucose accumulation in fructose-treated Caenorhabditis elegans.Amino acids · 2026Article
- Effects of a High-Glucose Diet onACS omega · 2026Article
- Coffee Silverskin Supplementation Alleviates High-Glucose-Diet-Induced Obesity by Modulating Lipogenic Gene Expression inMolecules (Basel, Switzerland) · 2026Article
- Article
- The Antioxidant and Antiaging Properties of Maillard Reaction Products Derived From Dipeptide Lys-Leu inFood science & nutrition · 2026Article
- Radiolabeling of Angiostrongylus vasorum- and Crenosoma striatum larvae: a novel method using PET/CT to unveil larval migration in the gastropod intermediate host (Lissachatina fulica).Parasites & vectors · 2025Article
- Glucose promotes neuron morphology abnormalities and egg-laying defects dependent of the serotonin signaling pathway inbioRxiv : the preprint server for biology · 2025Article
- High Nutritional Conditions Influence Feeding Plasticity in Pristionchus pacificus and Render Worms Non-Predatory.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Mitochondrial polarization and redox homeostasis couple glycolysis-to-OXPHOS metabolic rewiring to lifespan extension inmicroPublication biology · 2025Article
- Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells.PLoS computational biology · 2025Article
- High-glucose diets differentially modulate phosphatidylcholine metabolism and fecundity inFrontiers in cell and developmental biology · 2025Article
- The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extendActa pharmaceutica Sinica. B · 2024Article
- Glucose-fed microbiota alters C. elegans intestinal epithelium and increases susceptibility to multiple bacterial pathogens.Scientific reports · 2024Article
- The combination of metformin and high glucose increased longevity ofFrontiers in endocrinology · 2024Article
- Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans.PloS one · 2024Article
- Oleic Acid Metabolism in Response to Glucose inMetabolites · 2023Article
- Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration.BMC biology · 2023Article
- The role of nutrition and oxidative stress as aging factors inJournal of clinical biochemistry and nutrition · 2023Article
- A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.Development (Cambridge, England) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signaling, but the participation of other signaling pathways have not been addressed. In this study, we have determined that worms fed with high-glucose diets show alterations in glucose content and uptake, triglyceride content, body size, number of eggs laid, egg-laying defects, and signs of oxidative stress and accelerated aging. Additionally, we analyzed the participation of different key regulators of carbohydrate and lipid metabolism, oxidative stress and longevity such as SKN-1/NRF2, HIF-1/HIF1α, SBP-1/SREBP, CRH-1/CREB, CEP-1/p53, and DAF-16/FOXO, in the reduction of lifespan in glucose-fed worms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.