SynthesisPloS one2018
Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04267809 (Modulating Endoplasmic Reticulum Stress as a Prophylactic Approach Against Symptomatic Viral Infection), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulating Endoplasmic Reticulum Stress as a Prophylactic Approach Against Symptomatic Viral Infection
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- The magnitude of flaviviruses infection in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Diabetes mellitus as a risk factor for severe dengue fever and West Nile fever: A meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Maternal infection with Zika virus and prevalence of congenital disorders in infants: systematic review and meta-analysis.Canadian journal of public health = Revue canadienne de sante publique · 2019Pooled it
- The double burden of diabetes and global infection in low and middle-income countries.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Pooled it
- Pooled it
- Impact of metabolic comorbidities on the clinical course of West Nile virus infection.Journal of endocrinological investigation · 2026Article
- Observational
- Spatiotemporal and Demographic Patterns of West Nile Neuroinvasive Disease in Vojvodina, Serbia, 2012-2025.Viruses · 2026Article
- Severe dengue in adults: Clinical features from the 2022 dengue outbreak at a Vietnamese tertiary hospital.PLoS neglected tropical diseases · 2025Article
- Non hepatotropic virus induced hepatitis - rising importance in a changing world.World journal of virology · 2025Review
- Inter-host diversity associated with age, sex, and menstrual cycle modulates clinical manifestations in DENV-2 patients.iScience · 2025Article
- A review of the mosquito-borne flaviviruses: Dengue virus and West Nile virus in Southern Africa.Virusdisease · 2025Review
- Epidemiology of Yellow Fever in Nigeria: Analysis of Climatic, Ecological, Socio-Demographic, and Clinical Factors Associated with Viral Positivity Among Suspected Cases Using National Surveillance Data, 2017-2023.Journal of epidemiology and global health · 2025Article
- Severe Organ Impairment Was Common in Elderly Individuals with Dengue in Guangdong, China.The American journal of tropical medicine and hygiene · 2024Article
- Review
- Modeling West Nile Virus transmission in birds and humans: Advantages of using a cellular automata approach.Infectious Disease Modelling · 2024Article
- Clinical profile and early severity predictors of dengue fever: Current trends for the deadliest dengue infection in Bangladesh in 2022.IJID regions · 2023Article
- Ecological Niche and Positive Clusters of Two West Nile Virus Vectors in Ontario, Canada.EcoHealth · 2023Article
- Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines.Current treatment options in infectious diseases · 2023Review
- Epidemiological and Clinical Characteristics of Patients with Dengue Fever in a Recent Outbreak in Oman: A Single Center Retrospective-cohort Study.Oman medical journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlavivirus diseases such as dengue fever (DENV), West Nile virus (WNV), Zika and yellow fever represent a substantial global public health concern. Preexisting chronic conditions such as cardiovascular diseases, diabetes, obesity, and asthma were thought to predict risk of progression to severe infections.
objectiveWe aimed to quantify the frequency of chronic comorbidities in flavivirus diseases to provide an estimate for their prevalence in severe and non-severe infections and examine whether chronic diseases contribute to the increased risk of severe viral expression.
methodsWe conducted a comprehensive search in PubMed, Ovid MEDLINE(R), Embase and Embase Classic and grey literature databases to identify studies reporting prevalence estimates of comorbidities in flavivirus diseases. Study quality was assessed with the risk of bias tool. Age-adjusted odds ratios (ORs) were estimated for severe infection in the presence of chronic comorbidities.
resultsWe identified 65 studies as eligible for inclusion for DENV (47 studies) and WNV (18 studies). Obesity and overweight (i.e., BMI> 25 kg/m2, prevalence: 24.5%, 95% CI: 18.6-31.6%), hypertension (17.1%, 13.3-21.8%) and diabetes (13.3%, 9.3-18.8%) were the most prevalent comorbidities in DENV. However, hypertension (45.0%, 39.1-51.0%), diabetes (24.7%, 20.2-29.8%) and heart diseases (25.6%, 19.5-32.7%) were the most prevalent in WNV. ORs of severe flavivirus diseases were about 2 to 4 in infected patients with comorbidities such as diabetes, hypertension and heart diseases. The small number of studies in JEV, YFV and Zika did not permit estimating the prevalence of comorbidities in these infections.
conclusionHigher prevalence of chronic comorbidities was found in severe cases of flavivirus diseases compared to non-severe cases. Findings of the present study may guide public health practitioners and clinicians to evaluate infection severity based on the presence of comorbidity, a critical public health measure that may avert severe disease outcome given the current dearth of clear prevention practices for some flavivirus diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.