ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2018
Analysis of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Cancer After Chemoradiation to Identify High-Risk Patients for Adjuvant Chemotherapy: A Randomized Controlled Trial.
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Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 7 of them syntheses that pooled it.
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122citing papers in PubMed, 7 pooled it
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 7 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- SEOM-TTCC clinical guideline for nasopharyngeal carcinoma (update 2025).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Guideline
- Circulating tumor DNA in Non-Viral head and neck squamous cell Carcinoma: A systematic review and Meta-Analysis.Oral oncology · 2025Pooled it
- The effect of circulating tumor DNA on the prognosis of patients with head and neck squamous cell carcinoma: a systematic review and meta-analysis.BMC cancer · 2024Pooled it
- Weekly versus triweekly cisplatin treatment in patients with locally advanced nasopharyngeal cancer during concurrent chemoradiotherapy.European journal of medical research · 2023Pooled it
- Biomarkers predicting clinical outcomes in nasopharyngeal cancer patients receiving immune checkpoint inhibitors: A systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- SEOM-TTCC clinical guideline in nasopharynx cancer (2021).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Guideline
- Association of Chemoradiotherapy Regimens and Survival Among Patients With Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Anti-PD-1 antibody penpulimab plus chemotherapy for recurrent or metastatic nasopharyngeal carcinoma: a randomized, double-blind phase 3 study.Signal transduction and targeted therapy · 2026Trial
- Toripalimab plus anlotinib in patients with recurrent or metastatic nasopharyngeal carcinoma: A multicenter, single-arm phase 2 trial (TORAL).Cell reports. Medicine · 2024Trial
- Trial
- A Phase Ib Study of Lucitanib (AL3810) in a Cohort of Patients with Recurrent and Metastatic Nasopharyngeal Carcinoma.The oncologist · 2022Trial
- Association of Plasma Epstein-Barr Virus DNA With Outcomes for Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma Receiving Anti-Programmed Cell Death 1 Immunotherapy.JAMA network open · 2022Trial
- Efficacy, safety, and biomarker analysis of Camrelizumab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma (CAPTAIN study).Journal for immunotherapy of cancer · 2021Trial
- Trial
- Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Trial
- Rapid Clearance Profile of Plasma Circulating Tumor HPV Type 16 DNA during Chemoradiotherapy Correlates with Disease Control in HPV-Associated Oropharyngeal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Trial
- Cost-effectiveness of adjuvant therapy with camrelizumab in high-risk locoregionally advanced nasopharyngeal carcinoma: from the perspective of the Chinese healthcare system.Annals of medicine · 2026Article
- Nasopharyngeal carcinoma: epidemiology, risk factors, signaling pathways, clinical features, diagnosis, and management.Molecular biomedicine · 2026Review
- A time-adapted risk stratification framework guided by longitudinal post-radiotherapy EBV DNA clearance for high-risk nasopharyngeal carcinoma patients.Radiation oncology (London, England) · 2026Article
- New insights into the treatment of nasopharyngeal carcinoma in children, adolescents, and young adults: a retrospective study.Frontiers in immunology · 2026Article
62 more citing papers are in PubMed but not listed here.
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20 authors at 1 institution in 1 country.
Anthony T C ChanAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Edwin P HuiAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Roger K C NganAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Stewart Y TungAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Ashley C K ChengAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Wai T NgAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Victor H F LeeAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Brigette B Y MaAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Hoi C ChengAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Frank C S WongAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Herbert H F LoongAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Macy TongAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Darren M C PoonAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Anil T AhujaAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Ann D KingAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Ki WangAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Frankie MoAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Benny C Y ZeeAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
K C Allen ChanAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Y M Dennis LoAnthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Macy Tong, and Darren M.C. Poon, Prince of Wales Hospital; Roger K.C. Ngan and Hoi C. Cheng, Queen Elizabeth Hospital; Stewart Y. Tung and Frank C.S. Wong, Tuen Mun Hospital; Ashley C.K. Cheng, Princess Margaret Hospital; Wai T. Ng, Pamela Youde Nethersole Eastern Hospital; Victor H.F. Lee, Queen Mary Hospital; and Anthony T.C. Chan, Edwin P. Hui, Brigette B.Y. Ma, Herbert H.F. Loong, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, and Y.M. Dennis Lo, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China.
Princess Margaret Hospital · HK
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose The contribution of adjuvant chemotherapy after chemoradiation therapy (CRT) in nasopharyngeal cancer (NPC) remains controversial. Plasma Epstein-Barr virus (EBV) DNA is a potential biomarker of subclinical residual disease in NPC. In this prospective, multicenter, randomized controlled trial, we used plasma EBV DNA to identify patients with NPC at a higher risk of relapse for adjuvant chemotherapy. Patients and Methods Eligible patients with histologically confirmed NPC of Union for International Cancer Control stage IIB to IVB, adequate organ function, and no locoregional disease or distant metastasis were screened by plasma EBV DNA at 6 to 8 weeks after radiotherapy (RT). Patients with undetectable plasma EBV DNA underwent standard surveillance. Patients with detectable plasma EBV DNA were randomly assigned to either adjuvant chemotherapy with cisplatin and gemcitabine for six cycles (arm 1) or observation (arm 2). Patients were stratified for primary treatment (RT v CRT) and stage (II/III v IV). The primary end point was relapse-free survival (RFS). Results Seven hundred eighty-nine patients underwent EBV DNA screening. Plasma EBV DNA was undetectable in 573 (72.6%) and detectable in 216 (27.4%); 104 (13.2%) with detectable EBV DNA were randomly assigned to arms 1 (n = 52) and 2 (n = 52). After a median follow-up of 6.6 years, no significant difference was found in 5-year RFS rate between arms 1 and 2 (49.3% v 54.7%; P = .75; hazard ratio for relapse or death, 1.09; 95% CI, 0.63 to 1.89). The level of post-RT plasma EBV DNA correlated significantly with the hazards of locoregional failure, distant metastasis, and death. Conclusion In patients with NPC with detectable post-RT plasma EBV DNA, adjuvant chemotherapy with cisplatin and gemcitabine did not improve RFS. Post-RT plasma EBV DNA level should be incorporated as the selection factor in future clinical trials of adjuvant therapy in NPC.
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