Evidence map›Paper›PMID 29989857›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2018

Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203.

Ann H Klopp, Anamaria R Yeung, Snehal Deshmukh, Karen M Gil, Lari Wenzel, Shannon N Westin, Kent Gifford, David K Gaffney, William Small, Spencer Thompson and 12 more

Erratum issued 3 registry-linked trialsAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 148 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01672892 phase3completednot on this map

A Randomized Phase III Study of Standard vs. IMRT Pelvic Radiation for Post-Operative Treatment of Endometrial and Cervical Cancer (TIME-C)

TypeinterventionalSponsorRadiation Therapy Oncology GroupRan2012 to 2022Enrolled289ConditionsCervical Cancer, Endometrial Cancer, Gastrointestinal Complications, Perioperative/Postoperative ComplicationsArmsStandard radiation therapy, intensity-modulated radiation therapy
NCT03935256 phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Phase II Study of Concurrent and Sequential Carboplatin and Paclitaxel With Adjuvant Radiotherapy for High Risk Endometrial Cancer

TypeinterventionalSponsorLoyola UniversityRan2019 to 2024Enrolled24ConditionsEndometrial CancerArmsCarboplatin and Paclitaxel, Radiation Therapy
NCT07435623 recruitingnot on this mapstarted 2025, after this paper: background citation

Assessment of Late Gastrointestinal and Genitourinary Toxicities in Cervical and Endometrial Cancer Requiring Postoperative IMRT and/or Brachytherapy

TypeobservationalSponsorTata Memorial HospitalRan2025 to 2026Enrolled300ConditionsEndometrial Cancer, Cervix Cancer
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.Virchows Archiv : an international journal of pathology · 2021
    Guideline
  6. Guideline
  7. Trial
  8. A phase II clinical trial ofFrontiers in nutrition · 2025
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Article
  18. Bridging gaps in care: medical student home visits and their influence on radiation oncology patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  19. Article
  20. Article

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Ann H KloppAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Anamaria R YeungAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Snehal DeshmukhAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Karen M GilAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Lari WenzelAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Shannon N WestinAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Kent GiffordAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
David K GaffneyAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
William SmallAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Spencer ThompsonAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Desiree E DoncalsAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Guilherme H C CantuariaAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Brian P YaremkoAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Amy ChangAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Vijayananda KundapurAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Dasarahally S MohanAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Michael L HaasAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Yong Bae KimAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Catherine L FergusonAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Stephanie L PughAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Lisa A KachnicAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.
Deborah W BrunerAnn H. Klopp, Shannon N. Westin, and Kent Gifford, MD Anderson Cancer Center, Houston, TX; Anamaria R. Yeung, University of Florida, Gainsville, FL; Snehal Deshmukh and Stephanie L. Pugh, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Karen M. Gil, Summa Health System; Desiree E. Doncals, Summa Akron City Hospital, Akron, OH; Lari Wenzel, University of California Medical Center at Irvine, Irvine, CA; David K. Gaffney, University of Utah, Salt Lake City, UT; William Small Jr, Loyola University Medical Center, Maywood, IL; Spencer Thompson, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Guilherme H.C. Cantuaria, Northside Hospital, Atlanta, GA; Brian P. Yaremko, London Regional Cancer Program, London, Ontario; Vijayananda Kundapur, Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada; Amy Chang, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong; Dasarahally S. Mohan, Kaiser Permanente Cancer Treatment Center, South San Francisco, CA; Michael L. Haas, Reading Hospital, West Reading, PA; Yong Bae Kim, Yonsei University Health System-Severance Hospital, Seoul, South Korea; Catherine L. Ferguson, Georgia Regents University, Augusta; Deborah W. Bruner, Emory University, Atlanta, GA; and Lisa A. Kachnic, Vanderbilt University, Nashville, TN.

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mei-Yin C Polley · 2014 to 2026
$146.4M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS UG1 CA189867
6 · The paper itself

Abstract

Purpose NRG Oncology/RTOG 1203 was designed to compare patient-reported acute toxicity and health-related quality of life during treatment with standard pelvic radiation or intensity-modulated radiation therapy (IMRT) in women with cervical and endometrial cancer. Methods Patients were randomly assigned to standard four-field radiation therapy (RT) or IMRT radiation treatment. The primary end point was change in patient-reported acute GI toxicity from baseline to the end of RT, measured with the bowel domain of the Expanded Prostate Cancer Index Composite (EPIC). Secondary end points included change in patient-reported urinary toxicity, change in GI toxicity measured with the Patient-Reported Outcome Common Terminology Criteria for Adverse Events, and quality of life measured with the Trial Outcome Index. Results From 2012 to 2015, 289 patients were enrolled, of whom 278 were eligible. Between baseline and end of RT, the mean EPIC bowel score declined 23.6 points in the standard RT group and 18.6 points in the IMRT group ( P = .048), the mean EPIC urinary score declined 10.4 points in the standard RT group and 5.6 points in the IMRT group ( P = .03), and the mean Trial Outcome Index score declined 12.8 points in the standard RT group and 8.8 points in the IMRT group ( P = .06). At the end of RT, 51.9% of women who received standard RT and 33.7% who received IMRT reported frequent or almost constant diarrhea ( P = .01), and more patients who received standard RT were taking antidiarrheal medications four or more times daily (20.4% v 7.8%; P = .04). Conclusion Pelvic IMRT was associated with significantly less GI and urinary toxicity than standard RT from the patient's perspective.

Indexed as

Endometrial NeoplasmsFemaleHumansPatient Reported Outcome MeasuresPelvisRadiation InjuriesRadiotherapyRadiotherapy, Intensity-ModulatedUterine Cervical Neoplasms

Identifiers

PMID29989857
PMCPMC6097832

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