Evidence map›Paper›PMID 29989549›Full record

ArticleeLife2018

Characterization of developmental and molecular factors underlying release heterogeneity at

Yulia Akbergenova, Karen L Cunningham, Yao V Zhang, Shirley Weiss, J Troy Littleton

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Activity-Dependent Increases in Quantal Size at theJournal of developmental biology · 2025
    Article
  9. Article
  10. Review
  11. Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. CaeLife · 2024
    Article
  16. CabioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Muscle-fiber specific genetic manipulation ofFrontiers in physiology · 2024
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yulia AkbergenovaThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Karen L CunninghamThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Yao V ZhangThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
Shirley WeissThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.
J Troy LittletonThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States.ORCID http://orcid.org/0000-0001-5576-2887

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
CHARACTERIZATION OF THE DROSOPHILA SYNAPTOTAGMIN FAMILYR01NS040296 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2000 to 2024
$7.9M
Imaging Synaptic Transmission of Individual Active ZonesR01MH104536 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI J. TROY LITTLETON · 2014 to 2026
$4.7M
NIGMS NIH HHS T32 GM007287NIH HHS MH104536NIH HHS P40 OD018537NIH HHS T32GM007287NIMH NIH HHS R01 MH104536NINDS NIH HHS R01 NS040296
6 · The paper itself

Abstract

Neurons communicate through neurotransmitter release at specialized synaptic regions known as active zones (AZs). Using biosensors to visualize single synaptic vesicle fusion events at

Indexed as

AnimalsCalciumCells, CulturedDrosophilaDrosophila ProteinsExocytosisFemaleMaleMutationNeuronsNeurotransmitter AgentsPresynaptic TerminalsReceptors, Ionotropic GlutamateSynapsesSynaptic TransmissionSynaptic VesiclesCalciumDrosophila Proteinsglutamate receptor IIA, DrosophilaNeurotransmitter AgentsReceptors, Ionotropic GlutamateSynaptotagmin Iactive zonecalcium channelsD. melanogasterglutamate receptorsneurosciencesynapsesynapse developmentsynaptic plasticity

Identifiers

PMID29989549
PMCPMC6075867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.