Evidence map›Paper›PMID 29989526›Full record

ArticleRadiology2018

Bariatric Arterial Embolization: Effect of Microsphere Size on the Suppression of Fundal Ghrelin Expression and Weight Change in a Swine Model.

Yingli Fu, Clifford R Weiss, Kalyan Paudel, Eun-Ji Shin, Dorota Kedziorek, Aravind Arepally, Robert A Anders, Dara L Kraitchman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Angiographic Revascularization after Bariatric Embolization in a Swine Model.Journal of vascular and interventional radiology : JVIR · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Rationale and Preclinical Data Supporting Bariatric Arterial Embolization.Techniques in vascular and interventional radiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yingli FuFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Clifford R WeissFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).ORCID 0000-0003-2180-1731
Kalyan PaudelFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Eun-Ji ShinFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Dorota KedziorekFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Aravind ArepallyFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Robert A AndersFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Dara L KraitchmanFrom the Russell H. Morgan Department of Radiology and Radiological Science (Y.F., C.R.W., K.P., D.K., D.L.K.), Department of Gastroenterology (E.J.S.), and Department of Pathology (R.A.A.), the Johns Hopkins University School of Medicine, 1800 Orleans St, Zayed Tower 7203, Baltimore, MD 21287; and Department of Radiology, Piedmont Healthcare, Atlanta, Ga (A.A.).
Johns Hopkins University · US

Funding

Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of ObesityR01EB017615 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI KRAITCHMAN, DARA L, WEISS, CLIFFORD RAABE · 2013 to 2016
$1.4M
NIBIB NIH HHS R01 EB017615
6 · The paper itself

Abstract

Purpose To determine whether microsphere size effects ghrelin expression and weight gain after selective bariatric arterial embolization (BAE) in swine. Materials and Methods BAE was performed in 10 swine by using smaller (100-300 μm; n = 5) or larger (300-500 μm; n = 5) calibrated microspheres into gastric arteries. Nine control pigs underwent a sham procedure. Weight and fasting plasma ghrelin levels were measured at baseline and weekly for 16 weeks. Ghrelin-expressing cells (GECs) in the stomach were assessed by using immunohistochemical staining and analyzed by using the Wilcoxon rank-sum test. Results In pigs treated with smaller microspheres, mean weight gain at 16 weeks (106.9% ± 15.0) was less than in control pigs (131.9% ± 11.6) (P < .001). Mean GEC density was lower in the gastric fundus (14.8 ± 6.3 vs 25.0 ± 6.9, P < .001) and body (27.5 ± 12.3 vs 37.9 ± 11.8, P = .004) but was not significantly different in the gastric antrum (28.2 ± 16.3 vs 24.3 ± 11.6, P = .84) and duodenum (9.2 ± 3.8 vs 8.7 ± 2.9, P = .66) versus in control pigs. BAE with larger microspheres failed to suppress weight gain or GECs in any stomach part compared with results in control swine. Plasma ghrelin levels were similar between BAE pigs and control pigs, regardless of microsphere size. Week 1 endoscopic evaluation for gastric ulcers revealed none in control pigs, five ulcers in five pigs embolized by using smaller microspheres, and three ulcers in five pigs embolized by using larger microspheres. Conclusion In bariatric arterial embolization, smaller microspheres rather than larger microspheres showed greater weight gain suppression and fundal ghrelin expression with more gastric ulceration in a swine model. © RSNA, 2018.

Indexed as

Embolization, TherapeuticAnimalsFemaleGastric ArteryGhrelinMicrospheresParticle SizeStomachSwineWeight GainGhrelin

Identifiers

PMID29989526
PMCPMC6166770
OpenAlexW2866872937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.