Trial reportJournal of aging and physical activity2019
2,000 Steps/Day Does Not Fully Protect Skeletal Muscle Health in Older Adults During Bed Rest.
Trial report in Journal of aging and physical activity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The role of muscle disuse in muscular and cardiovascular fitness: A systematic review and meta-regression.European journal of sport science · 2024Pooled it
- The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- Two-week step-reduction has limited negative effects on physical function and metabolic health in older adults.European journal of applied physiology · 2024Trial
- Post-operative electrical muscle stimulation attenuates loss of muscle mass and function following major abdominal surgery in older adults: a split body randomised control trial.Age and ageing · 2022Trial
- Countering disuse atrophy in older adults with low-volume leucine supplementation.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Impact of 14 days of head-down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults.Experimental physiology · 2026Article
- Bidirectional association of daily steps with sarcopenia: a longitudinal study.Annals of medicine · 2025Article
- What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025Review
- Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest.The Journal of physiology · 2025Article
- Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.Journal of functional morphology and kinesiology · 2025Article
- [Bed confinement in old people-A literature review].Zeitschrift fur Gerontologie und Geriatrie · 2025Article
- Becoming Bedridden and Being Bedridden: Implications for Nursing and Care for Older People in Long-Term Care: A Scoping Review.International journal of older people nursing · 2025Article
- From molecular to physical function: The aging trajectory.Current research in physiology · 2025Review
- Post-discharge light physical activity indicates recovery in acutely hospitalized older adults - the Hospital-ADL study.BMC geriatrics · 2023Observational
- Important Concepts in Protein Nutrition, Aging, and Skeletal Muscle: Honoring Dr Douglas Paddon-Jones (1969-2021) by Highlighting His Research Contributions.The Journal of nutrition · 2023Review
- The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults.Scientific reports · 2022Article
- Prevalence risk of sarcopenia in older Brazilian adults during the pandemic: A cross-sectional analysis of the Remobilize Study.Sao Paulo medical journal = Revista paulista de medicina · 2022Observational
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
- Improvements in sleep quality and fatigue are associated with improvements in functional recovery following hospitalization in older adults.Frontiers in sleep · 2022Article
- Practical applications of whey protein in supporting skeletal muscle maintenance, recovery, and reconditioning.Journal of animal science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Physical activity in an inpatient setting is often limited to brief periods of walking. For healthy adults, public health agencies recommend a minimum of 150 min/week of moderate-intensity exercise. The authors sought to determine if meeting this activity threshold, in the absence of incidental activities of daily living, could protect skeletal muscle health during bed rest. Healthy older adults (68 ± 2 years) were randomized to 7-day bed rest with (STEP, n = 7) or without (CON, n = 10) a 2,000 steps/day intervention. Performing 2018 ± 4 steps/day did not prevent the loss of lean leg mass and had no beneficial effect on aerobic capacity, strength, or muscle fiber volume. However, the insulin response to an oral glucose challenge was preserved. Performing a block of 2,000 steps/day, in the absence of incidental activities of daily living, was insufficient to fully counter the catabolic effects of bed rest in healthy older adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.