Evidence map›Paper›PMID 29989178›Full record

ArticleTransfusion2018

Risk factors for peripartum blood transfusion in South Africa: a case-control study.

Evan M Bloch, Charlotte Ingram, Jennifer Hull, Susan Fawcus, John Anthony, Randolph Green-Thompson, Robert L Crookes, Solomuzi Ngcobo, Darryl V Creel, Lauren Courtney and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Maternal anemia is associated with adverse maternal and neonatal outcomes in Mbarara, Uganda.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Evan M BlochDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Charlotte IngramSouth African National Blood Service, Johannesburg, South Africa.
Jennifer HullDepartment of Obstetrics and Gynecology, Chris Hani Baragwanath Hospital, Soweto, South Africa.
Susan FawcusDepartment of Obstetrics and Gynecology, Mowbray Maternity Hospital.
John AnthonyDepartment of Obstetrics and Gynecology, Groote Schuur Hospital, Cape Town, South Africa.
Randolph Green-ThompsonDepartment of Obstetrics and Gynecology, King Edward Hospital, Durban, South Africa.
Robert L CrookesSouth African National Blood Service, Johannesburg, South Africa.
Solomuzi NgcoboSouth African National Blood Service, Johannesburg, South Africa.
Darryl V CreelRTI international, Rockville, Maryland.
Lauren CourtneyRTI international, Rockville, Maryland.
Greg R M BellairsWestern Province Blood Transfusion Service, Cape Town, South Africa.
Edward L MurphyBlood Systems Research Institute, San Francisco, California.
South Africa Program of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)
South African National Blood Service · ZABlood Systems Research Institute · USChris Hani Baragwanath Hospital · ZAGroote Schuur Hospital · ZAKing Edward VIII Hospital · ZAUniversity of California, San Francisco · USUniversity of Pretoria · ZA

Funding

NHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009IWHI NIH HHS HHSN268201100002C
6 · The paper itself

Abstract

backgroundObstetric hemorrhage (OH) and access to peripartum blood transfusion remains a global health challenge. The rates of peripartum transfusion in South Africa exceed those in high-income countries despite comparable rates of OH. We sought to evaluate factors associated with peripartum transfusion. STUDY DESIGN AND

methodsA case-control study was conducted at four large South African hospitals. Transfused peripartum women (cases) and nontransfused controls were stratum matched 1:2 by hospital and delivery date. Data on obstetric, transfusion, and human immunodeficiency virus (HIV) history were abstracted from medical records. Blood was obtained for laboratory evaluation. We calculated unadjusted and adjusted odds ratios (ORs) for transfusion using logistic regression.

resultsA total of 1200 transfused cases and 2434 controls were evaluated. Antepartum hemorrhage (OR, 197.95; 95% confidence interval [CI], 104.27-375.78), hemorrhage with vaginal delivery (OR, 136.46; 95% CI, 75.87-245.18), prenatal anemia (OR, 22.76; 95% CI, 12.34-41.93 for prenatal hemoglobin level < 7 g/dL), and failed access to prenatal care (OR, 6.71; 95% CI, 4.32-10.42) were the major risk factors for transfusion. Platelet (PLT) count (ORs, 4.10, 2.66, and 1.77 for ≤50 × 10

conclusionMajor risk factors of peripartum transfusion in South Africa, namely, prenatal anemia and access to prenatal care, may be amenable to intervention. HIV infection and moderately low PLT count are novel risk factors that merit further investigation.

Indexed as

AdolescentAdultAnemiaBirth WeightBlood TransfusionCase-Control StudiesCesarean SectionFemaleGestational AgeHealth Services AccessibilityHIV InfectionsHumansInfant, NewbornOdds RatioPostoperative ComplicationsPostpartum Hemorrhage

Identifiers

PMID29989178
PMCPMC6167140
OpenAlexW2815415197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.