Evidence map›Paper›PMID 29989050›Full record

ArticleKidney international reports2018

Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania.

David W Ploth, Jessie K Mbwambo, Virginia A Fonner, Bruce Horowitz, Phillip Zager, Ron Schrader, Francis Fredrick, Caroline Laggis, Michael D Sweat

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

David W PlothDepartment of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina, USA.
Jessie K MbwamboDepartment of Psychiatry and Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Virginia A FonnerDepartment of Psychiatry and Behavioral Sciences, Division of Global and Community Health, Medical University of South Carolina, Charleston, South Carolina, USA.
Bruce HorowitzDivision of Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Phillip ZagerDepartment of Medicine, Division of Nephrology, University of New Mexico, Albuquerque, New Mexico, USA.
Ron SchraderDepartment of Medicine, Division of Nephrology, University of New Mexico, Albuquerque, New Mexico, USA.
Francis FredrickSchool of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Caroline LaggisDepartment of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Michael D SweatDepartment of Psychiatry and Behavioral Sciences, Division of Global and Community Health, Medical University of South Carolina, Charleston, South Carolina, USA.
Medical University of South Carolina · USMuhimbili University of Health and Allied Sciences · TZUniversity of New Mexico · USUniversity of Utah · US

Funding

Impact of Integrated HIV/NCD Screening on HIV Testing Uptake and Engagement in HIV Care: An RCT in Kisarawe, TanzanizR01MH111366 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SWEAT, MICHAEL D · 2016 to 2021
$3.2M
Phase II RCT of Comprehensive Triaged HIV Prevention: Tanzania (Supplement)R01MH095869 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SWEAT, MICHAEL D · 2012 to 2015
$1.8M
NIMH NIH HHS R01 MH095869NIMH NIH HHS R01 MH111366
6 · The paper itself

Abstract

introductionChronic kidney disease (CKD), diabetes, and hypertension play a disproportionate role in the growing public health challenge posed by noncommunicable diseases (NCDs) in East Africa. The impact of these NCDs may pose the greatest challenge in rural areas with limited screening and treatment facilities, although precise prevalence estimates of these conditions in rural Tanzania are lacking.

methodsThe prevalence of CKD, diabetes, and hypertension, were estimated from a probability sample of adults (n = 739) residing in 2 communities within Kisarawe, a rural district of Tanzania. Following consent, participants were studied in their homes. Random point-of-care (POC) measures of glycosylated hemoglobin and blood pressure, were obtained. Serum creatinine, drawn at the POC and measured at Muhimbili National University, was used to calculate estimated glomerular filtration rate with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.

resultsThe median age was 35 years (interquartile range 25-45 years). Overall the pooled prevalence for CKD stages III, IV, and V was 12.4% (95% confidence interval [CI] = 10.2-14.8). Surprisingly, the prevalence of CKD stage V (3.0%; 95% CI = 2.1-4.4) was high among the youngest age group (18-36 years). The prevalence estimates for prehypertension and hypertension were 38.0% (95% CI = 34.6-41.5) and 19.9% (95% CI = 17.1-22.9), respectively. The prevalence estimates for prediabetes and diabetes were 25.7% (95% CI = 22.6-29.1) and 14.8% (95% CI = 12.4-17.6), respectively.

conclusionAlthough this pilot study had a relatively small sample size, the prevalence estimates for CKD, diabetes, and hypertension were higher than we expected based on previous estimates from Tanzania. CKD was not significantly associated with diabetes or hypertension, suggesting the possibility of an alternative causality.

Indexed as

diabetes mellitushypertensionkidney diseaseprevalenceTanzania

Identifiers

PMID29989050
PMCPMC6035140
OpenAlexW2802115717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.