Evidence map›Paper›PMID 29989023›Full record

ReviewKidney international reports2018

Regenerative Medicine and Immunomodulatory Therapy: Insights From the Kidney, Heart, Brain, and Lung.

Christopher J Pino, Angela J Westover, Kimberly A Johnston, Deborah A Buffington, H David Humes

Open access · goldAbstract readReview
In one paragraph

Review in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

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  16. Novel function ofIranian journal of basic medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christopher J PinoInnovative BioTherapies, Inc., Ann Arbor, Michigan, USA.
Angela J WestoverInnovative BioTherapies, Inc., Ann Arbor, Michigan, USA.
Kimberly A JohnstonInnovative BioTherapies, Inc., Ann Arbor, Michigan, USA.
Deborah A BuffingtonInnovative BioTherapies, Inc., Ann Arbor, Michigan, USA.
H David HumesInnovative BioTherapies, Inc., Ann Arbor, Michigan, USA.
Innovative BioTherapies (United States) · USUniversity of Michigan–Ann Arbor · US

Funding

Phase 2 Study of Selective Cytopheretic Device for the Treatment of Pediatric Patients with Acute Kidney Injury R01FD005092 · FDA · INNOVATIVE BIOTHERAPIES, INC. · PI GOLDSTEIN, STUART L, HUMES, H. DAVID · 2015 to 2018
$976k
Biomimetic Membrane Device for Therapeutic Application in Chronic Heart FailureR43HL118792 · NHLBI · INNOVATIVE BIOTHERAPIES, INC. · PI BUFFINGTON, DEBORAH ANN · 2015 to 2015
$655k
FDA HHS R01 FD005092NHLBI NIH HHS R43 HL118792
6 · The paper itself

Abstract

Regenerative medicine was initially focused on tissue engineering to replace damaged tissues and organs with constructs derived from cells and biomaterials. More recently, this field of inquiry has expanded into exciting areas of translational medicine modulating the body's own endogenous processes, to prevent tissue damage in organs and to repair and regenerate these damaged tissues. This review will focus on recent insights derived from studies in which the manipulation of the innate immunologic system may diminish acute kidney injury and enhance renal repair and recovery without the progression to chronic kidney disease and renal failure. The manner in which these interventions may improve acute and chronic organ dysfunction, including the heart, brain, and lung, will also be reviewed.

Indexed as

acute kidney injurymedical deviceselective cytopheretic devicetranslational medicine

Identifiers

PMID29989023
PMCPMC6035130
OpenAlexW2782188610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.