Evidence map›Paper›PMID 29988980›Full record

ArticleKidney international reports2018

Local Adipose-Associated Mediators and Adaptations Following Arteriovenous Fistula Creation.

Gaurav Sharma, Christopher Kuppler, Yong He, Ming Tao, Kui Ding, Alban Longchamp, Laura M Dember, C Keith Ozaki, Scott A Berceli

Abstract read
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gaurav SharmaDivision of Vascular and Endovascular Surgery, Brigham and Women's Heart and Vascular Center/Harvard Medical School, Boston, Massachusetts, USA.
Christopher KupplerMalcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA.
Yong HeMalcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA.
Ming TaoDivision of Vascular and Endovascular Surgery, Brigham and Women's Heart and Vascular Center/Harvard Medical School, Boston, Massachusetts, USA.
Kui DingDivision of Vascular and Endovascular Surgery, Brigham and Women's Heart and Vascular Center/Harvard Medical School, Boston, Massachusetts, USA.
Alban LongchampDivision of Vascular and Endovascular Surgery, Brigham and Women's Heart and Vascular Center/Harvard Medical School, Boston, Massachusetts, USA.
Laura M DemberRenal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
C Keith OzakiDivision of Vascular and Endovascular Surgery, Brigham and Women's Heart and Vascular Center/Harvard Medical School, Boston, Massachusetts, USA.
Scott A BerceliMalcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA.

Funding

ADVANCED TRAINING IN SURGICAL ONCOLOGYT32CA009535 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUENO, RAPHAEL · 1985 to 2015
$3.5M
Determinants of Hemodialysis AV Fistula MaturationU01DK082232 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DEMBER, LAURA M · 2008 to 2012
$2.4M
Modulation of the Hemodynamic Factors Associated with AVF MaturationU01DK082189 · NIDDK · UNIVERSITY OF FLORIDA · PI HUBER, THOMAS S · 2008 to 2012
$1.8M
Adipose Dependent Mechanisms of Dietary Protein Restriction Protective Effects on Vein Graft AdaptationsR01HL133500 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OZAKI, C KEITH · 2016 to 2019
$1.7M
Inflammation and Repair as Determinants of Hemodialysis Fistula MaturationR01DK091443 · NIDDK · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 2011 to 2014
$1.5M
NCI NIH HHS T32 CA009535NHLBI NIH HHS R01 HL133500NIDDK NIH HHS R01 DK091443NIDDK NIH HHS U01 DK082189NIDDK NIH HHS U01 DK082232
6 · The paper itself

Abstract

introductionLocal inflammation is an important regulator of vascular remodeling. We hypothesized that adipose tissue adjacent to hemodialysis arteriovenous fistulae modulates maturation.

methodsDuring fistula creation, perivenous adipose was collected from 111 participants in the Hemodialysis Fistula Maturation Study. Nine adipose-associated mediators were measured. Duplex ultrasound was performed at 4 time points postoperatively from 1 day to first cannulation (10-26 weeks). Associations between logarithmically transformed biomarker levels and fistula remodeling were evaluated using mixed effects regression.

resultsElevated interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1 were associated with a reduction in the fractional vein diameter during the early time frame of 1 day to 2 weeks (diameter change of 26.6% and 20.4% at the 25th and 75th percentile for IL-6,

conclusionThus, impaired fistula vein dilation and reduced capacity for flow augmentation associate with specific local adipose phenotypic signatures in a time-dependent manner. In view of adipose tissue plasticity, these findings raise the possibility of novel adipose-based strategies to facilitate fistula maturation.

Indexed as

chronic kidney diseasefistula maturationhemodialysisinflammationperivascular adipose tissue

Identifiers

PMID29988980
PMCPMC6035127

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.