Evidence map›Paper›PMID 29988890›Full record

ArticlePhotoacoustics2018

A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT).

Clinton W Hupple, Stefan Morscher, Neal C Burton, Mark D Pagel, Lacey R McNally, Julio Cárdenas-Rodríguez

Abstract read
In one paragraph

Article in Photoacoustics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  14. Review
  15. Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals.Frontiers in bioengineering and biotechnology · 2021
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clinton W HuppleiThera Medical GmbH, München, Germany.
Stefan MorscheriThera Medical GmbH, München, Germany.
Neal C BurtoniThera Medical GmbH, München, Germany.
Mark D PagelDepartment of Medical Imaging, University of Arizona, Tucson, AZ, USA.
Lacey R McNallyDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Julio Cárdenas-RodríguezDepartment of Medical Imaging, University of Arizona, Tucson, AZ, USA.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Detection of in vivo enzyme activities with CEST MRIR01CA169774 · NCI · UNIVERSITY OF ARIZONA · PI CARDENAS-RODRIGUEZ, JULIO · 2012 to 2016
$2.5M
Measuring extracellular pH in pre-clinical tumor models with CEST MRIR01CA167183 · NCI · UNIVERSITY OF ARIZONA · PI PAGEL, MARK DAVID · 2012 to 2015
$1.6M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA167183NCI NIH HHS R01 CA169774
6 · The paper itself

Abstract

MultiSpectral Optoacoustic Tomography (MSOT) is an emerging imaging technology that allows for data acquisition at high spatial and temporal resolution. These imaging characteristics are advantageous for Dynamic Contrast Enhanced (DCE) imaging that can assess the combination of vascular flow and permeability. However, the quantitative analysis of DCE MSOT data has not been possible due to complications caused by wavelength-dependent light attenuation and variability in light fluence at different anatomical locations. In this work we present a new method for the quantitative analysis of DCE MSOT data that is not biased by light fluence. We have named this method the two-compartment linear standard model (2C-LSM) for DCE MSOT.

Indexed as

Dynamic contrast enhanced imagingLinear modelsMultispectral optoacoustic tomographyPermeabilityPharmacokinetics models

Identifiers

PMID29988890
PMCPMC6033053

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.