Evidence map›Paper›PMID 29988862›Full record

ArticleWorld journal of hepatology2018

Responsibility of hepatitis C virus in the development of hepatocellular carcinoma: From molecular alterations to possible solutions.

Gaetano Bertino, Giulia Malaguarnera, Evelise Frazzetto, Alice Sciuto, Gaetano Inserra, Guido Nicola Zanghì, Michele Malaguarnera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gaetano BertinoHepatology Unit, Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Catania 95123, Italy. gaetanobertinounict@g.mail.com.
Giulia MalaguarneraResearch Center "the Great Senescence", University of Catania, Catania 95100, Italy.
Evelise FrazzettoHepatology Unit, Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Catania 95123, Italy.
Alice SciutoHepatology Unit, Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", Catania 95123, Italy.
Gaetano InserraInternal Medicine Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy.
Guido Nicola ZanghìDepartment of Surgery, Policlinico Vittorio Emanuele University Hospital, University of Catania, Catania 95100, Italy.
Michele MalaguarneraResearch Center "the Great Senescence", University of Catania, Catania 95100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are several causes of hepatocellular carcinoma (HCC), but certainly the hepatitis C virus (HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents (DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.

Indexed as

Direct acting antiviralsFibrosisHepatitis C virusHepatocellular carcinomaInflammationInsulin-resistanceOxidative stress

Identifiers

PMID29988862
PMCPMC6033714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.