Evidence map›Paper›PMID 29988835›Full record

ArticlePhotoacoustics2018

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy.

J Aguirre, B Hindelang, Andrei Berezhnoi, U Darsow, F Lauffer, K Eyerich, T Biedermann, V Ntziachristos

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026
    Review
  5. Non-invasive characterization of melanoma depth at single-cell resolution.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  6. Review
  7. Review
  8. Journal of biomedical optics · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. New perspectives in the imaging of Raynaud's phenomenon.European journal of rheumatology · 2020
    Review
  20. Clinical photoacoustic imaging.Photoacoustics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

J AguirreChair of Biological Imaging, Technische Universität München and Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
B HindelangDepartment of Dermatology and Allergy, Technische Universität München, Munich, Germany.
Andrei BerezhnoiChair of Biological Imaging, Technische Universität München and Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
U DarsowDepartment of Dermatology and Allergy, Technische Universität München, Munich, Germany.
F LaufferDepartment of Dermatology and Allergy, Technische Universität München, Munich, Germany.
K EyerichDepartment of Dermatology and Allergy, Technische Universität München, Munich, Germany.
T BiedermannDepartment of Dermatology and Allergy, Technische Universität München, Munich, Germany.
V NtziachristosChair of Biological Imaging, Technische Universität München and Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Technical University of Munich · DEHelmholtz Zentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nailfold capillaroscopy, based on bright-field microscopy, is widely used to diagnose systemic sclerosis (SSc). However it cannot reveal information about venules and arterioles lying deep under the nailfold, nor can it provide detailed data about surface microvasculature when the skin around the nail is thick. These limitations reflect the fact that capillaroscopy is based on microscopy methods whose penetration depth is restricted to about 200 μm. We investigated whether ultra-wideband raster-scan optoacoustic mesoscopy (UWB-RSOM) can resolve small capillaries of the nailfold in healthy volunteers and compared the optoacoustic data to conventional capillaroscopy examinations. We quantified UWB-RSOM-resolved capillary density and capillary diameter as features that relate to SSc biomarkers, and we obtained the first three-dimensional,

Identifiers

PMID29988835
PMCPMC6032507
OpenAlexW2791672656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.